[3] Purdue Univ, Sch Chem Engn, W Lafayette, IN 47907 USA
来源:
26TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING (ESCAPE), PT A
|
2016年
/
38A卷
基金:
英国工程与自然科学研究理事会;
关键词:
milling;
particle breakage;
modelling;
dynamics;
population balance;
PHARMACEUTICAL POWDERS;
BEHAVIOR;
D O I:
10.1016/B978-0-444-63428-3.50084-9
中图分类号:
TQ [化学工业];
学科分类号:
0817 ;
摘要:
A particle-scale breakage model for impact milling has been proposed by Vogel and Peukert based on single particle impact experiments. Their model provides a good starting point for extension to dynamic systems, since it successfully separates the effects of material properties from the milling operating conditions. In the current study, a rigorous way to incorporate such a single particle breakage model into a dynamic population balance model is proposed by considering the particle breakages under different numbers of successive impacts, each with distinct impact rates, breakage probabilities, and breakage functions. The new model was developed within both Process System Enterprise's gSOLIDS and MathWorks' MATLAB software and has been verified with experimental data. Notably good matches between the predicted and experimental data were obtained.
机构:
New Jersey Inst Technol, Otto H York Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USANew Jersey Inst Technol, Otto H York Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USA
Capece, Maxx
Bilgili, Ecevit
论文数: 0引用数: 0
h-index: 0
机构:
New Jersey Inst Technol, Otto H York Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USANew Jersey Inst Technol, Otto H York Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USA
Bilgili, Ecevit
Dave, Rajesh N.
论文数: 0引用数: 0
h-index: 0
机构:
New Jersey Inst Technol, Otto H York Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USANew Jersey Inst Technol, Otto H York Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USA
机构:
AstraZeneca, Pharmaceut Dev, Global Med Dev, Macclesfield SK10 2NA, Cheshire, EnglandAstraZeneca, Pharmaceut Dev, Global Med Dev, Macclesfield SK10 2NA, Cheshire, England
Gavi, Emmanuela
Reynolds, Gavin K.
论文数: 0引用数: 0
h-index: 0
机构:
AstraZeneca, Pharmaceut Dev, Global Med Dev, Macclesfield SK10 2NA, Cheshire, EnglandAstraZeneca, Pharmaceut Dev, Global Med Dev, Macclesfield SK10 2NA, Cheshire, England
机构:
New Jersey Inst Technol, Otto H York Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USANew Jersey Inst Technol, Otto H York Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USA
Capece, Maxx
Bilgili, Ecevit
论文数: 0引用数: 0
h-index: 0
机构:
New Jersey Inst Technol, Otto H York Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USANew Jersey Inst Technol, Otto H York Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USA
Bilgili, Ecevit
Dave, Rajesh N.
论文数: 0引用数: 0
h-index: 0
机构:
New Jersey Inst Technol, Otto H York Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USANew Jersey Inst Technol, Otto H York Dept Chem Biol & Pharmaceut Engn, Newark, NJ 07102 USA
机构:
AstraZeneca, Pharmaceut Dev, Global Med Dev, Macclesfield SK10 2NA, Cheshire, EnglandAstraZeneca, Pharmaceut Dev, Global Med Dev, Macclesfield SK10 2NA, Cheshire, England
Gavi, Emmanuela
Reynolds, Gavin K.
论文数: 0引用数: 0
h-index: 0
机构:
AstraZeneca, Pharmaceut Dev, Global Med Dev, Macclesfield SK10 2NA, Cheshire, EnglandAstraZeneca, Pharmaceut Dev, Global Med Dev, Macclesfield SK10 2NA, Cheshire, England