Quantitative Optical Coherence Tomography Angiography Biomarkers for Alport Syndrome

被引:1
作者
Cunha, Ana Maria [1 ]
Teixeira, Daniela [2 ]
Cabral, Diogo [3 ]
Estrela-Silva, Sergio [1 ,4 ]
Falcao-Reis, Fernando [1 ,4 ]
Carneiro, Angela [1 ,4 ]
机构
[1] Ctr Hosp Univ Sao Joao, Dept Ophthalmol, Porto, Portugal
[2] Univ Porto, Fac Med, Porto, Portugal
[3] Inst Oftalmol Dr Gama Pinto, Lisbon, Portugal
[4] Univ Porto, Dept Surg & Physiol, Fac Med, Porto, Portugal
关键词
Alport syndrome; Optical coherence tomography angiography; Spectral-domain optical coherence tomography; Quantitative biomarkers; COLLAGEN-IV; ABNORMALITIES; RETINOPATHY; MUTATIONS;
D O I
10.1159/000519242
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: The aim of this study was to evaluate microvascular abnormalities of patients with Alport syndrome (AS) using optical coherence tomography angiography (OCT-A) quantitative biomarkers. Methods: This was cross sectional, prospective evaluation of consecutive patients with AS and healthy subjects. AS diagnosis was performed by the genetic test. All participants underwent a retinal vasculature evaluation by spectral-domain optical coherence tomography (SD-OCT) and OCT-A of the macula. Quantitative analysis included whole vascular density, foveal avascular zone area, fractal dimension (FD), and lacunarity (LAC). Results: Ninety-four eyes were included in this study, 45 eyes from patients with AS and 49 eyes from healthy subjects. The pathogenic mutation in the COL4A5 gene on the chromosome X was found in 14 patients; the pathogenic autosomal recessive mutations in the COL4A3 gene were found in 9 patients. Quantitative evaluation demonstrated a significant difference between AS and healthy subjects on LAC of the superficial capillary plexus and deep capillary plexus (DCP) (p < 0.001 and p < 0.001, respectively) and on FD in the DCP (p < 0.001). Conclusion: The DCP Alport patients have a higher vessel nonuniformity than DCP of healthy subjects. We hypothesize that endothelial cell lesion in the setting of low resistance at the DCP circuit could lead to long-term structural disorganization. (C) 2021 S. Karger AG, Basel
引用
收藏
页码:41 / 48
页数:8
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