Human Pluripotent Stem Cells: Myths and Future Realities for Liver Cell Therapy

被引:11
作者
Goldman, Orit [1 ]
Gouon-Evans, Valerie [1 ]
机构
[1] Icahn Sch Med Mt Sinai, Black Family Stem Cell Inst, Dept Dev & Regenerat Biol, New York, NY 10029 USA
关键词
HUMAN FIBROBLASTS; HEPATOCYTES; CULTURE;
D O I
10.1016/j.stem.2016.05.019
中图分类号
Q813 [细胞工程];
学科分类号
摘要
The severe shortage of organ donors for treating patients with liver disease has prompted in vitro efforts to produce the main functional cells of the liver: hepatocyte-like cells (Hep cells). We consider the key challenges posed by various stem cell technologies and liver pathologies for developing clinically useful Hep cells.
引用
收藏
页码:703 / 706
页数:4
相关论文
共 10 条
[1]   Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming [J].
Du, Yuanyuan ;
Wang, Jinlin ;
Jia, Jun ;
Song, Nan ;
Xiang, Chengang ;
Xu, Jun ;
Hou, Zhiyuan ;
Su, Xiaohua ;
Liu, Bei ;
Jiang, Tao ;
Zhao, Dongxin ;
Sun, Yingli ;
Shu, Jian ;
Guo, Qingliang ;
Yin, Ming ;
Sun, Da ;
Lu, Shichun ;
Shi, Yan ;
Deng, Hongkui .
CELL STEM CELL, 2014, 14 (03) :394-403
[2]   Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes [J].
Huang, Pengyu ;
Zhang, Ludi ;
Gao, Yimeng ;
He, Zhiying ;
Yao, Dan ;
Wu, Zhitao ;
Cen, Jin ;
Chen, Xiaotao ;
Liu, Changcheng ;
Hu, Yiping ;
Lai, Dongmei ;
Hu, Zhenlei ;
Chen, Li ;
Zhang, Ying ;
Cheng, Xin ;
Ma, Xiaojun ;
Pan, Guoyu ;
Wang, Xin ;
Hui, Lijian .
CELL STEM CELL, 2014, 14 (03) :370-384
[3]   Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver [J].
Huch, Meritxell ;
Gehart, Helmuth ;
van Boxtel, Ruben ;
Hamer, Karien ;
Blokzijl, Francis ;
Verstegen, Monique M. A. ;
Ellis, Ewa ;
van Wenum, Martien ;
Fuchs, Sabine A. ;
de Ligt, Joep ;
van de Wetering, Marc ;
Sasaki, Nobuo ;
Boers, Susanne J. ;
Kemperman, Hans ;
de Jonge, Jeroen ;
Ijzermans, Jan N. M. ;
Nieuwenhuis, Edward E. S. ;
Hoekstra, Ruurdtje ;
Strom, Stephen ;
Vries, Robert R. G. ;
van der Laan, Luc J. W. ;
Cuppen, Edwin ;
Clevers, Hans .
CELL, 2015, 160 (1-2) :299-312
[4]   Cell competition leads to a high level of normal liver reconstitution by transplanted fetal liver stem/progenitor cells [J].
Oertel, M ;
Menthena, A ;
Dabeva, MD ;
Shafritz, DA .
GASTROENTEROLOGY, 2006, 130 (02) :507-520
[5]   Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes [J].
Ogawa, Shinichiro ;
Surapisitchat, James ;
Virtanen, Carl ;
Ogawa, Mina ;
Niapour, Maryam ;
Sugamori, Kim S. ;
Wang, Shuang ;
Tamblyn, Laura ;
Guillemette, Chantal ;
Hoffmann, Ewa ;
Zhao, Bin ;
Strom, Stephen ;
Laposa, Rebecca R. ;
Tyndale, Rachel F. ;
Grant, Denis M. ;
Keller, Gordon .
DEVELOPMENT, 2013, 140 (15) :3285-3296
[6]   In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis [J].
Rezvani, Milad ;
Espanol-Suner, Regina ;
Malato, Yann ;
Dumont, Laure ;
Grimm, Andrew A. ;
Kienle, Eike ;
Bindman, Julia G. ;
Wiedtke, Ellen ;
Hsu, Bernadette Y. ;
Naqvi, Syed J. ;
Schwabe, Robert F. ;
Corvera, Carlos U. ;
Grimm, Dirk ;
Willenbring, Holger .
CELL STEM CELL, 2016, 18 (06) :809-816
[7]   Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis [J].
Song, Guangqi ;
Pacher, Martin ;
Balakrishnan, Asha ;
Yuan, Qinggong ;
Tsay, Hsin-Chieh ;
Yang, Dakai ;
Reetz, Julia ;
Brandes, Sabine ;
Dai, Zhen ;
Puetzer, Brigitte M. ;
Arauzo-Bravo, Marcos J. ;
Steinemann, Doris ;
Luedde, Tom ;
Schwabe, Robert F. ;
Manns, Michael P. ;
Schoeler, Hans R. ;
Schambach, Axel ;
Cantz, Tobias ;
Ott, Michael ;
Sharma, Amar Deep .
CELL STEM CELL, 2016, 18 (06) :797-808
[8]   Vascularized and functional human liver from an iPSC-derived organ bud transplant [J].
Takebe, Takanori ;
Sekine, Keisuke ;
Enomura, Masahiro ;
Koike, Hiroyuki ;
Kimura, Masaki ;
Ogaeri, Takunori ;
Zhang, Ran-Ran ;
Ueno, Yasuharu ;
Zheng, Yun-Wen ;
Koike, Naoto ;
Aoyama, Shinsuke ;
Adachi, Yasuhisa ;
Taniguchi, Hideki .
NATURE, 2013, 499 (7459) :481-+
[9]   Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells [J].
Yusa, Kosuke ;
Rashid, S. Tamir ;
Strick-Marchand, Helene ;
Varela, Ignacio ;
Liu, Pei-Qi ;
Paschon, David E. ;
Miranda, Elena ;
Ordonez, Adriana ;
Hannan, Nicholas R. F. ;
Rouhani, Foad J. ;
Darche, Sylvie ;
Alexander, Graeme ;
Marciniak, Stefan J. ;
Fusaki, Noemi ;
Hasegawa, Mamoru ;
Holmes, Michael C. ;
Di Santo, James P. ;
Lomas, David A. ;
Bradley, Allan ;
Vallier, Ludovic .
NATURE, 2011, 478 (7369) :391-+
[10]   Mouse liver repopulation with hepatocytes generated from human fibroblasts [J].
Zhu, Saiyong ;
Rezvani, Milad ;
Harbell, Jack ;
Mattis, Aras N. ;
Wolfe, Alan R. ;
Benet, Leslie Z. ;
Willenbring, Holger ;
Ding, Sheng .
NATURE, 2014, 508 (7494) :93-97