Selective inhibitors of nuclear export (SINE)- a novel class of anti-cancer agents

被引：121

作者：

Parikh, Kaushal ^{[1
,2
]}

Cang, Shundong ^{[3
]}

Sekhri, Arunabh ^{[1
,2
]}

Liu, Delong ^{[4
]}

机构：

[1] New York Med Coll, Dept Med, Valhalla, NY 10595 USA

[2] Westchester Med Ctr, Valhalla, NY 10595 USA

[3] Peoples Hosp Henan Prov, Dept Oncol, Zhengzhou, Peoples R China

[4] Zhengzhou Univ, Henan Tumor Hosp, Zhengzhou 450052, Peoples R China

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2014年 / 7卷

关键词：

SINE; KPT-330; Selinexor; Nuclear export; CHRONIC LYMPHOCYTIC-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; RECEPTOR SIGNALING PATHWAY; CELL LUNG-CANCER; IMPROVED SURVIVAL; DRUG-RESISTANCE; CRM1; INHIBITOR; C/EBP-ALPHA; EGFR-TKIS; APOPTOSIS;

D O I：

10.1186/s13045-014-0078-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dysregulation of the nucleo-cytoplasmic transport of proteins plays an important role in carcinogenesis. The nuclear export of proteins depends on the activity of transport proteins, exportins. Exportins belong to the karyopherin beta superfamily. Exportin-1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), mediates transport of around 220 proteins. In this review, we summarized the development of a new class of antitumor drugs, collectively known as selective inhibitors of nuclear export (SINE). KPT-330 (selinexor) as an oral agent is showing activities in early clinical trials in both solid tumors and hematological malignancies.

引用

页数：8

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