Hospitalization Risks for Neurological Disorders in Primary Sjogren's Syndrome Patients

被引：4

作者：

Goulabchand, Radjiv ^{[1
,2
,3
]}

Gabelle, Audrey ^{[2
,4
,5
]}

Ayrignac, Xavier ^{[2
,6
,7
]}

Malafaye, Nicolas ^{[8
]}

Labauge, Pierre ^{[2
,6
,7
]}

Noel, Daniele ^{[3
]}

Morel, Jacques ^{[2
,9
,10
]}

Roubille, Camille ^{[2
,11
]}

Barateau, Lucie ^{[2
,7
,12
]}

Guilpain, Philippe ^{[2
,3
,13
]}

Mura, Thibault ^{[2
,14
]}

机构：

[1] Univ Montpellier, CHU Nimes, Internal Med Dept, F-30029 Nimes, France

[2] Univ Montpellier, Sch Med, F-30060 Montpellier, France

[3] Univ Montpellier, Inst Regenerat Med & Biotherapy IRMB, INSERM, U1183, F-34090 Montpellier, France

[4] Montpellier Univ Hosp, Dept Neurol, Memory Res & Resources Alzheimer Ctr, F-34090 Montpellier, France

[5] Univ Montpellier, Neuropsychiat Epidemiol & Clin Res, INSERM, U1061, F-34090 Montpellier, France

[6] Montpellier Univ Hosp, Dept Neurol, CRC SEP, F-34090 Montpellier, France

[7] Univ Montpellier, Inst Neurosci Montpellier INM, INSERM, F-34090 Montpellier, France

[8] Montpellier Univ Hosp, Dept Med Informat, F-34295 Montpellier, France

[9] Montpellier Univ Hosp, Dept Rheumatol, F-34295 Montpellier, France

[10] Univ Montpellier, PhyMedExp, INSERM, U1046,CNRS,UMR 9214, F-34295 Montpellier, France

[11] Montpellier Univ Hosp, Dept Internal Med, F-34295 Montpellier, France

[12] Montpellier Univ Hosp, Dept Neurol, Sleep Wake Disorders Unit, F-34090 Montpellier, France

[13] Montpellier Univ Hosp, Dept Internal Med & Multiorgan Dis, F-34090 Montpellier, France

[14] Univ Montpellier, CHU Nimes, Dept Biostat Clin Epidemiol Publ Hlth & Innovat M, F-30029 Nimes, France

来源：

JOURNAL OF CLINICAL MEDICINE | 2022年 / 11卷 / 07期

关键词：

primary Sjogren's syndrome; dementia; multiple sclerosis; encephalitis; peripheral neuropathy; COMORBIDITIES EXCLUDING LYMPHOMA; INVOLVEMENT;

D O I：

10.3390/jcm11071979

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Primary Sjogren's syndrome (pSS) can be associated with neurological and cognitive involvement, negatively affecting patients' quality of life. The aim of this study was to assess whether pSS patients are at higher risk of hospitalization for neurological diseases. Through a nationwide retrospective study using the French Health insurance database (based on International Classification for Disease codes, ICD-10), we selected patients hospitalized with new-onset pSS between 2011 and 2018. We compared the incidence of hospitalization for dementia, multiple sclerosis (MS), encephalitis, and peripheral neuropathy with an age- and sex-matched (1:10) hospitalized control group. Adjusted Hazard Ratios (aHR) considered confounding factors, particularly socio-economic status and cardiovascular diseases. We analyzed 25,661 patients hospitalized for pSS, compared with 252,543 matched patients. The incidence of hospitalization for dementia was significantly higher in pSS patients (aHR = 1.27 (1.04-1.55); p = 0.018), as well as the incidence of hospitalization for MS, encephalitis, and inflammatory polyneuropathies (aHR = 3.66 (2.35-5.68), p < 0.001; aHR = 2.66 (1.22-5.80), p = 0.014; and aHR = 23.2 (12.2-44.5), p < 0.001, respectively). According to ICD-10 codes, pSS patients exhibited a higher incidence of hospitalization for dementia, encephalitis, MS, and peripheral neuropathies than controls. Physicians must be aware of these neurological risks to choose the most appropriate diagnostic work-up.

引用

页数：9

共 42 条

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