Ethyl 6-[4-(dimethylamino)phenyl]-4-hydroxy-2-oxo-4-(trifluoromethyl)hexahydropyrimidine-5-carboxylate

被引:5
|
作者
Song, Xiao-Ping [1 ]
Li, Gong-Chun [1 ]
Wu, Chang-Zeng [1 ]
Yang, Feng-Ling [1 ]
机构
[1] Xuchang Univ, Coll Chem & Chem Engn, Xuchang 461000, Henan Province, Peoples R China
关键词
MITOTIC KINESIN EG5;
D O I
10.1107/S1600536810013127
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
The title compound, C(16)H(20)F(3)N(3)O(4), was prepared by reaction of 4-(dimethylamino) benzaldehyde, ethyl 4,4,4-trifluoro-3-oxobutanoate and urea. In the title molecule, the pyrimidine ring adopts a half-chair conformation and there is an intramolecular hydrogen bond (O-H center dot center dot center dot O). The crystal structure is stabilized by two types intermolecular hydrogen bonds (N-H center dot center dot center dot O and N-H center dot center dot center dot N).
引用
收藏
页码:O1083 / U151
页数:10
相关论文
共 50 条
  • [1] Study on the synthesis, structural, spectroscopic, thermal, DFT and NLO property of ethyl 4-hydroxy-2-Oxo-6-(Thiophen-3-yl)-4-(Trifluoromethyl) hexahydropyrimidine-5-carboxylate (EHTHPC)
    Sathiya, S.
    Senthilkumar, M.
    JOURNAL OF MOLECULAR STRUCTURE, 2020, 1203
  • [2] Ethyl 6-(4-fluorophenyl)-4-hydroxy-2-oxo-4-trifluoromethyl-1,3-diazinane-5-carboxylate monohydrate
    Li, Gong-Chun
    Wu, Chang-Zeng
    Guo, Li-Li
    Yang, Feng-Ling
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O1704 - U846
  • [3] Synthesis, spectroscopic, chemical reactivity, topology analysis and molecular docking study of ethyl 5-hydroxy-2-thioxo-4-(p-tolyl)-6-(trifluoromethyl) hexahydropyrimidine-5-carboxylate
    Umadevan, I.
    Rajasekaran, R.
    Bennet, M. Anto
    Rajmohan, V.
    Vetrivelan, V.
    Sankar, K.
    Raja, M.
    HELIYON, 2024, 10 (03)
  • [4] Crystal structure of ethyl 4-[4-(dimethylamino)-phenyl]-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahyaroquinoline-3-carboxylate
    Steiger, Scott A.
    Li, Chun
    Natale, Nicholas R.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2018, 74 : 1417 - +
  • [5] Ethyl 6-(4-fluorophenyl)-4-hydroxy-2-sulfanylidene-4-trifluoromethyl-1,3-diazinane-5-carboxylate
    Huang, Bao-Jun
    Zhu, Lei
    He, Qin
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O880 - U3244
  • [6] Crystal structures of ethyl 6-(4-methylphenyl)-4-oxo-4H-chromene-2-carboxylate and ethyl 6-(4-fluorophenyl)-4-oxo-4H-chromene-2-carboxylate
    Gomes, Ligia R.
    Low, John Nicolson
    Fernandes, Carlos
    Gaspar, Alexandra
    Borges, Fernanda
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2016, 72 : 8 - +
  • [7] rac-Ethyl 4-hydroxy-6-(2-hydroxyphenyl)-2-oxo-4-(trifluoromethyl)perhydropyrimidine-5-carboxylate
    Song, Xiao-Ping
    Li, Gong-Chun
    Zhu, Feng-Xiang
    Wu, Chang-Zeng
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O1651 - U111
  • [8] Synthesis, structural, spectroscopical and DFT studies on third order NLO crystal: Ethyl-5‑hydroxy‑4-(2-hydroxyphenyl)-2-oxo-6-(trifluoromethyl) hexahydropyrimidine5-carboxylate (EHOTHPC)
    Sathiya, S.
    Senthilkumar, M.
    Umarani, P.
    Journal of Molecular Structure, 2022, 1224
  • [9] Ethyl 2-[4-(dimethylamino) phenyl]-1-phenyl-1H-benzimidazole-5-carboxylate
    Yeong, Keng Yoon
    Ali, Mohamed Ashraf
    Choon, Tan Soo
    Rosli, Mohd Mustaqim
    Razak, Ibrahim Abdul
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2013, 69 : O886 - +
  • [10] Ethyl 1-phenyl-2-[4-(trifluoromethyl)-phenyl]-1H-benzimidazole-5-carboxylate
    Yoon, Yeong Keng
    Ali, Mohamed Ashraf
    Choon, Tan Soo
    Arshad, Suhana
    Razak, Ibrahim Abdul
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O1864 - +