Alzheimer's disease and sleep disturbances: a review

被引：28

作者：

Borges, Conrad Regis ^{[1
]}

Poyares, Dalva ^{[2
]}

Piovezan, Ronald ^{[2
]}

Nitrini, Ricardo ^{[1
]}

Brucki, Sonia ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Med, Hosp Clin, Dept Neurol,Grp Neurol Cognit & Comportamento, Sao Paulo, SP, Brazil

[2] Univ Fed Sao Paulo, Escola Paulista Med, Inst Sono, Sao Paulo, SP, Brazil

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2019年 / 77卷 / 11期

关键词：

Alzheimer disease; sleep initiation and maintenance disorders; cognitive dysfunction; MILD COGNITIVE IMPAIRMENT; CIRCADIAN ACTIVITY RHYTHMS; INCIDENT DEMENTIA; NEUROPSYCHIATRIC SYMPTOMS; DAYTIME SLEEPINESS; BETA DYNAMICS; OLDER-ADULTS; REM-SLEEP; RISK; DISORDERS;

D O I：

10.1590/0004-282X20190149

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The association between Alzheimer's disease (AD) and sleep disturbances has received increasing scientific attention in the last decades. However, little is known about the impact of sleep and its disturbances on the development of preclinical AD stages, such as mild cognitive impairment. This review describes the evolution of knowledge about the potential bidirectional relationships between AD and sleep disturbances exploring recent large prospective studies and meta-analyses and studies of the possible mechanisms through which sleep and the neurodegenerative process could be associated. The review also makes a comprehensive exploration of the sleep characteristics of older people, ranging from cognitively normal individuals, through patients with mild cognitive impairment, up to the those with dementia with AD.

引用

页码：815 / 824

页数：10

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