Depsidones from Talaromyces stipitatus SK-4, an endophytic fungus of the mangrove plant Acanthus ilicifolius

被引：28
作者：
Cai, Runlin [1 ]
Chen, Senhua [1 ]
Long, Yuhua [1 ,2 ]
Li, Chunyuan [3 ]
Huang, Xishan [1 ]
She, Zhigang [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Chem, 135 Xingang West Rd, Guangzhou 510275, Guangdong, Peoples R China
[2] South China Normal Univ, Sch Chem & Environm, Guangzhou 510006, Guangdong, Peoples R China
[3] South China Agr Univ, Coll Mat & Energy, Guangzhou 510642, Guangdong, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2017年 / 20卷
基金：
中国国家自然科学基金;
关键词：
Endophytic fungus; Talaromyces stipitatus; Depsidones; Antibacterial activity; alpha-Glucosidase inhibitory activity; SECONDARY METABOLITES; PURPACTIN-A; BIOSYNTHESIS; DERIVATIVES; PENICILLIDE; PRODUCTS; FLAVUS;
D O I：
10.1016/j.phytol.2017.04.023
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
An endophytic fungus (Talaromyces stipitatus SK-4) was isolated from the leaves of a mangrove plant Acanthus ilicifolius. Its crude extract exhibited significant antibacterial activity and was purified to afford two new depsidones, talaromyones A and B (1 and 2), along with five known depsidone analogs (3-7). Their structures, including absolute configuration, were elucidated through extensive spectroscopic data analysis and modified Mosher's method. Compound 2 showed antibacterial activity against Bacillus subtilis with an MIC value of 12.5 mu g/mL. In the inhibitory assay against alpha-glucosidase, compounds 2, 4 and 5 displayed moderate activities with IC50 values ranging from 48.4 to 99.8 mu M.
引用
收藏
页码：196 / 199
页数：4
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