Recent Insights into Emerging Coronavirus: SARS-CoV-2

被引：24
作者：
Shang, Zifang [1 ,2 ]
Chan, Siew Yin [1 ,2 ]
Liu, William J. [3 ]
Li, Peng [1 ,2 ]
Huang, Wei [1 ,2 ]
机构：
[1] Northwestern Polytech Univ, Xian Inst Flexible Elect IFE, Frontiers Sci Ctr Flexible Elect FSCFE, Xian 710072, Peoples R China
[2] Northwestern Polytech Univ, Xian Inst Biomed Mat & Engn IBME, Xian 710072, Peoples R China
[3] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, NHC Key Lab Biosafety, Beijing 102206, Peoples R China
来源：
ACS INFECTIOUS DISEASES | 2021年 / 7卷 / 06期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
SARS-CoV-2; COVID-19; pathogenesis; diagnosis; therapy; antibody; vaccine; inhibitor; transmission; pandemic; MEDIATED ISOTHERMAL AMPLIFICATION; CONVALESCENT PLASMA; SARS-CORONAVIRUS; SPIKE PROTEIN; ANTIBODIES; COVID-19; VACCINE; CHLOROQUINE; THERAPY;
D O I：
10.1021/acsinfecdis.0c00646
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The SARS-CoV-2 outbreak that emerged at the end of 2019 has affected more than 58 million people with more than 1.38 million deaths and has had an incalculable impact on the world. Extensive prevention and treatment measures have been implemented since the pandemic. In this Review, we summarize current understanding on the source, transmission characteristics, and pathogenic mechanism of SARS-CoV-2. We also detail the recent development of diagnostic methods and potential treatment strategies of COVID-19 with focus on the ongoing clinical trials of antibodies, vaccines, and inhibitors for combating the emerging coronavirus.
引用
收藏
页码：1369 / 1388
页数：20
相关论文
共 143 条
[21]   Rational Vaccine Design in the Time of COVID-19 [J].
Burton, Dennis R. ;
Walker, Laura M. .
CELL HOST & MICROBE, 2020, 27 (05) :695-698
[22]  
Cai YF, 2020, SCIENCE, V369, P1586, DOI [10.1126/science.abd4251, 10.1101/2020.05.16.099317]
[23]   Isolation and rapid sharing of the 2019 novel coronavirus (SAR-CoV-2) from the first patient diagnosed with COVID-19 in Australia [J].
Caly, Leon ;
Druce, Julian ;
Roberts, Jason ;
Bond, Katherine ;
Tran, Thomas ;
Kostecki, Renata ;
Yoga, Yano ;
Naughton, William ;
Taiaroa, George ;
Seemann, Torsten ;
Schultz, Mark B. ;
Howden, Benjamin P. ;
Korman, Tony M. ;
Lewin, Sharon R. ;
Williamson, Deborah A. ;
Catton, Mike G. .
MEDICAL JOURNAL OF AUSTRALIA, 2020, 212 (10) :459-462
[24]  
Cao B, 2020, NEW ENGL J MED, V382, P1787, DOI [10.1056/NEJMoa2001282, 10.1056/NEJMc2008043]
[25]  
Chen H, 2020, medRxiv, DOI [10.1101/2020.03.22.20034041, 10.1101/2020.03.22.20034041v1, DOI 10.1101/2020.03.22.20034041V1, 10.1101/2020.03.22.20034041]
[26]   Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records [J].
Chen, Huijun ;
Guo, Juanjuan ;
Wang, Chen ;
Luo, Fan ;
Yu, Xuechen ;
Zhang, Wei ;
Li, Jiafu ;
Zhao, Dongchi ;
Xu, Dan ;
Gong, Qing ;
Liao, Jing ;
Yang, Huixia ;
Hou, Wei ;
Zhang, Yuanzhen .
LANCET, 2020, 395 (10226) :809-815
[27]   Convalescent plasma as a potential therapy for COVID-19 [J].
Chen, Long ;
Xiong, Jing ;
Bao, Lei ;
Shi, Yuan .
LANCET INFECTIOUS DISEASES, 2020, 20 (04) :398-400
[28]   Use of convalescent plasma therapy in SARS patients in Hong Kong [J].
Cheng, Y ;
Wong, R ;
Soo, YOY ;
Wong, WS ;
Lee, CK ;
Ng, MHL ;
Chan, P ;
Wong, KC ;
Leung, CB ;
Cheng, G .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2005, 24 (01) :44-46
[29]   Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings [J].
Chu, CM ;
Cheng, VCC ;
Hung, IFN ;
Wong, MML ;
Chan, KH ;
Chan, KS ;
Kao, RYT ;
Poon, LLM ;
Wong, CLP ;
Guan, Y ;
Peiris, JSM ;
Yuen, KY .
THORAX, 2004, 59 (03) :252-256
[30]  
Clausen TM, 2020, CELL, V183, P1043, DOI [10.1016/j.cell.2020.09.033, 10.1101/2020.07.14.201616]
12345678910