Nonpeptide glycoprotein IIb/IIIa inhibitors: Substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists

被引：128

作者：

Liverton, NJ

Armstrong, DJ

Claremon, DA

Remy, DC

Baldwin, JJ

机构：

[1] Merck Sharp & Dohme Ltd, Res Labs, Dept Med Chem, W Point, PA 19486 USA

[2] Merck Sharp & Dohme Ltd, Res Labs, Dept Pharmacol, W Point, PA 19486 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(98)00047-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological activity of a series of 3,6-substituted quinazolinediones and quinazolinones are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of these structures as central templates for nonpeptide RGD mimics. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：483 / 486

页数：4

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