Progress in the Management of Pancreatic Neuroendocrine Tumors

被引：18

作者：

Chang, Amy ^{[1
]}

Sherman, Scott K. ^{[2
]}

Howe, James R. ^{[2
]}

Sahai, Vaibhav ^{[1
]}

机构：

[1] Univ Michigan, Dept Internal Med, Div Hematol & Oncol, Ann Arbor, MI 48109 USA

[2] Univ Iowa, Dept Surg, Div Surg Oncol & Endocrine Surg, Iowa City, IA 52242 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2022年 / 73卷

关键词：

ENDOTHELIAL GROWTH-FACTOR; SOCIETY CONSENSUS GUIDELINES; ZOLLINGER-ELLISON SYNDROME; PROGNOSTIC-FACTORS; LIVER METASTASES; 1ST-LINE CHEMOTHERAPY; MEDICAL-MANAGEMENT; ENDOCRINE TUMORS; SURVIVAL; EXPRESSION;

D O I：

10.1146/annurev-med-042320-011248

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pancreatic neuroendocrine tumors (PNETs) are a heterogeneous and orphan group of neoplasms that vary in their histology, clinical features, prognosis, and management. The treatment of PNETs is highly dependent on the stage at presentation, tumor grade and differentiation, presence of symptoms from hormonal overproduction or from local growth, tumor burden, and rate of progression. The US Food and Drug Administration has recently approved many novel treatments, which have altered decision making and positively impacted the care and prognosis of these patients. In this review, we focus on the significant progress made in the management of PNETs over the past decade, as well as the active areas of research.

引用

页码：213 / 229

页数：17

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