Intestinal stents: Structure, functionalization and advanced engineering innovation

被引：16

作者：

Feng, Yusheng ^{[1
]}

Chen, Yufeng ^{[2
]}

Chen, Ying ^{[3
]}

He, Xiaowen ^{[2
]}

Khan, Yousef ^{[3
]}

Hu, Hong ^{[4
]}

Lan, Ping ^{[2
]}

Li, Yi ^{[5
]}

Wang, Xiaoqin ^{[1
]}

Li, Gang ^{[1
]}

Kaplan, David ^{[3
]}

机构：

[1] Soochow Univ, Coll Text & Clothing Engn, Natl Engn Lab Modern Silk, Suzhou 215123, Jiangsu, Peoples R China

[2] Sun Yat Sen Univ, Sixth Affiliated Hosp, Dept Colorectal Surg, Guangdong Prov Key Lab Colorectal & Pelv Floor Di, Guangzhou 510655, Guangdong, Peoples R China

[3] Tufts Univ, Dept Biomed Engn, 4 Colby St, Medford, MA 02155 USA

[4] Hong Kong Polytech Univ, Inst Text & Clothing, Kowloon, Hong Kong, Peoples R China

[5] Univ Manchester, Dept Mat, Oxford Rd, Manchester M13 9PL, Lancs, England

来源：

BIOMATERIALS ADVANCES | 2022年 / 137卷

基金：

国家重点研发计划;

关键词：

Intestinal stents; Colorectal cancer; Drug delivery; Biodegradable; Functionalization; OBSTRUCTIVE COLORECTAL-CANCER; MALIGNANT COLONIC OBSTRUCTION; EXPANDING METALLIC STENTS; IN-VITRO DEGRADATION; BIODEGRADABLE STENTS; PHOTODYNAMIC THERAPY; POLYVINYL-ALCOHOL; LIVER METASTASES; UNCOVERED STENT; COVERED STENT;

D O I：

10.1016/j.bioadv.2022.212810

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Intestinal stents are a palliative treatment option that solves many shortcomings of traditional surgeries for cancer-induced intestinal obstructions. The present review provides an overview of the incidence, clinical manifestations and limitations in the treatment of intestinal cancers. The paper also discusses material property requirements, indications, complications and the future of stent-assisted therapy. The advantages and disadvantages of different materials and processing techniques for intestinal stents are reviewed along with new stent treatment combinations for colorectal cancer. Challenges that require further cooperative studies are also detailed. The future development of intestinal stents will depend on innovation in material designs as well as the utilization of multi-functional strategies and innovative engineering solutions.

引用

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