Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders

被引：94

作者：

Aliperti, Vincenza ^{[1
]}

Skonieczna, Justyna ^{[2
]}

Cerase, Andrea ^{[2
]}

机构：

[1] Univ Naples Federico II, Dept Biol, I-80126 Naples, Italy

[2] Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, Ctr Genom & Child Hlth, London E1 2AT, England

来源：

NON-CODING RNA | 2021年 / 7卷 / 02期

关键词：

long non-coding RNAs; neurodevelopment; neurological disorders; neurodegeneration; neuropsychiatric disorders; Alzheimer's disease (AZ); amyotrophic lateral sclerosis (ALS); autism spectrum disorder (ASD); schizophrenia (SZ); FRONTOTEMPORAL LOBAR DEGENERATION; DIPEPTIDE REPEAT PROTEIN; NON-CODING RNA; ALZHEIMERS-DISEASE; GENE-EXPRESSION; SUBCELLULAR-LOCALIZATION; COMPREHENSIVE ANALYSIS; MOLECULAR-MECHANISMS; NEURONAL DEVELOPMENT; MASTER REGULATORS;

D O I：

10.3390/ncrna7020036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain. Altered expression of lncRNAs has been linked to several neurodegenerative, neurodevelopmental and mental disorders. The identification and characterization of lncRNAs that are deregulated or mutated in neurodevelopmental and mental health diseases are fundamental to understanding the complex transcriptional processes in brain function. Crucially, lncRNAs can be exploited as a novel target for treating neurological disorders. In our review, we first summarize the recent advances in our understanding of lncRNA functions in the context of cell biology and then discussing their association with selected neuronal development and neurological disorders.

引用

页数：25

共 206 条

[21] Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies [J].