Regioselective palladium-catalyzed arylation of 3-carboalkoxy furan and thiophene

被引：230

作者：

Glover, B ^{[1
]}

Harvey, KA ^{[1
]}

Liu, B ^{[1
]}

Sharp, MJ ^{[1
]}

Tymoschenko, MF ^{[1
]}

机构：

[1] GlaxoSmithKline, Chem Dev, Res Triangle Pk, NC 27709 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 03期

关键词：

D O I：

10.1021/ol027266q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The regioselective palladium(0)-catalyzed arylation of 3-furoate and 3-thiophenecarboxylate esters with aryl bromides is described. Conditions were developed that allow for the selective synthesis of either 2-aryl or 5-aryl products.

引用

页码：301 / 304

页数：4

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