Durable complete response to nivolumab in a patient with HIV and metastatic non-small cell lung cancer

被引：31

作者：

McCullar, Brennan ^{[1
]}

Alloway, Taylor ^{[1
]}

Martin, Michael ^{[2
]}

机构：

[1] Univ Tennessee, Ctr Hlth Sci, Dept Internal Med, Memphis, TN 38163 USA

[2] West Canc Ctr, Memphis, TN USA

来源：

JOURNAL OF THORACIC DISEASE | 2017年 / 9卷 / 06期

关键词：

Nivolumab; metastatic non-small cell lung cancer (NSCLC); HIV; DOCETAXEL; SAFETY;

D O I：

10.21037/jtd.2017.05.32

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Programmed death 1 (PD-1) inhibitors have been shown to increase overall survival in non-small cell lung cancer (NSCLC) patients. HIV patients have increased expression of PD-1 on their T-cell surfaces. We describe a patient with well-controlled HIV and NSCLC who underwent treatment with nivolumab and had a durable complete response (CR) with his viral load remaining undetectable. To date there is only one case report of a cancer patient with melanoma and with HIV treated with a programmed death ligand 1 (PD-L1) inhibitor. The majority of clinical trials involving PD-1 and PD-L1 inhibitors exclude HIV patients.

引用

页码：E540 / E542

页数：3

共 13 条

[1] Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Borghaei, H. ;

Paz-Ares, L. ;

Horn, L. ;

Spigel, D. R. ;

Steins, M. ;

Ready, N. E. ;

Chow, L. Q. ;

Vokes, E. E. ;

Felip, E. ;

Holgado, E. ;

Barlesi, F. ;

Kohlhaeufl, M. ;

Arrieta, O. ;

Burgio, M. A. ;

Fayette, J. ;

Lena, H. ;

Poddubskaya, E. ;

Gerber, D. E. ;

Gettinger, S. N. ;

Rudin, C. M. ;

Rizvi, N. ;

Crino, L. ;

Blumenschein, G. R. ;

Antonia, S. J. ;

Dorange, C. ;

Harbison, C. T. ;

Finckenstein, F. Graf ;

Brahmer, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639

[2] Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer [J].

Brahmer, Julie ;

Reckamp, Karen L. ;

Baas, Paul ;

Crino, Lucio ;

Eberhardt, Wilfried E. E. ;

Poddubskaya, Elena ;

Antonia, Scott ;

Pluzanski, Adam ;

Vokes, Everett E. ;

Holgado, Esther ;

Waterhouse, David ;

Ready, Neal ;

Gainor, Justin ;

Aren Frontera, Osvaldo ;

Havel, Libor ;

Steins, Martin ;

Garassino, Marina C. ;

Aerts, Joachim G. ;

Domine, Manuel ;

Paz-Ares, Luis ;

Reck, Martin ;

Baudelet, Christine ;

Harbison, Christopher T. ;

Lestini, Brian ;

Spigel, David R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (02) :123-135

[3] Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer [J].

Brahmer, Julie R. ;

Tykodi, Scott S. ;

Chow, Laura Q. M. ;

Hwu, Wen-Jen ;

Topalian, Suzanne L. ;

Hwu, Patrick ;

Drake, Charles G. ;

Camacho, Luis H. ;

Kauh, John ;

Odunsi, Kunle ;

Pitot, Henry C. ;

Hamid, Omid ;

Bhatia, Shailender ;

Martins, Renato ;

Eaton, Keith ;

Chen, Shuming ;

Salay, Theresa M. ;

Alaparthy, Suresh ;

Grosso, Joseph F. ;

Korman, Alan J. ;

Parker, Susan M. ;

Agrawal, Shruti ;

Goldberg, Stacie M. ;

Pardoll, Drew M. ;

Gupta, Ashok ;

Wigginton, Jon M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (26) :2455-2465

[4] PD-1 Blockade in Advanced Melanoma in Patients with Hepatitis C and/or HIV [J].

Davar, Diwakar ;

Wilson, Melissa ;

Pruckner, Chelsea ;

Kirkwood, Johnm M. .

CASE REPORTS IN ONCOLOGICAL MEDICINE, 2015, 2015

[5]

Grabmeier-Pfistershammer Katharina, 2011, J Acquir Immune Defic Syndr, V56, P118, DOI 10.1097/QAI.0b013e3181fbab9f

[6] Safety and Tumor Responses with Lambrolizumab (Anti-PD-1) in Melanoma [J].

Hamid, Omid ;

Robert, Caroline ;

Daud, Adil ;

Hodi, F. Stephen ;

Hwu, Wen-Jen ;

Kefford, Richard ;

Wolchok, Jedd D. ;

Hersey, Peter ;

Joseph, Richard W. ;

Weber, Jeffrey S. ;

Dronca, Roxana ;

Gangadhar, Tara C. ;

Patnaik, Amita ;

Zarour, Hassane ;

Joshua, Anthony M. ;

Gergich, Kevin ;

Elassaiss-Schaap, Jeroen ;

Algazi, Alain ;

Mateus, Christine ;

Boasberg, Peter ;

Tumeh, Paul C. ;

Chmielowski, Bartosz ;

Ebbinghaus, Scot W. ;

Li, Xiaoyun Nicole ;

Kang, S. Peter ;

Ribas, Antoni .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (02) :134-144

[7] FDA Approval Summary: Nivolumab for the Treatment of Metastatic Non-Small Cell Lung Cancer With Progression On or After Platinum-Based Chemotherapy [J].

Kazandjian, Dickran ;

Suzman, Daniel L. ;

Blumenthal, Gideon ;

Mushti, Sirisha ;

He, Kun ;

Libeg, Meredith ;

Keegan, Patricia ;

Pazdur, Richard .

ONCOLOGIST, 2016, 21 (05) :634-642

[8]

Macatangay Bernard J C, 2009, Cellscience, V5, P61

[9] The blockade of immune checkpoints in cancer immunotherapy [J].

Pardoll, Drew M. .

NATURE REVIEWS CANCER, 2012, 12 (04) :252-264

[10] Responsiveness of HIV-specific CD4 T cells to PD-1 blockade [J].

Porichis, Filippos ;

Kwon, Douglas S. ;

Zupkosky, Jennifer ;

Tighe, Daniel P. ;

McMullen, Ashley ;

Brockman, Mark A. ;

Pavlik, David F. ;

Rodriguez-Garcia, Marta ;

Pereyra, Florencia ;

Freeman, Gordon J. ;

Kavanagh, Daniel G. ;

Kaufmann, Daniel E. .

BLOOD, 2011, 118 (04) :965-974

← 1 2 →