Inflammatory potential of the diet and risk of breast cancer in the European Investigation into Cancer and Nutrition (EPIC) study

被引：16

作者：

Castro-Espin, Carlota ^{[1
,2
,3
]}

Agudo, Antonio ^{[1
,2
,3
]}

Bonet, Catalina ^{[1
,2
,3
]}

Katzke, Verena ^{[4
]}

Turzanski-Fortner, Renee ^{[4
]}

Aleksandrova, Krasimira ^{[5
,6
]}

Schulze, Matthias B. ^{[6
,7
]}

Tjonneland, Anne ^{[8
]}

Dahm, Christina C. ^{[9
]}

Quiros, Jose-Ramon ^{[10
]}

Sanchez, Maria-Jose ^{[11
,12
,13
,14
]}

Amiano, Pilar ^{[13
,15
]}

Chirlaque, Maria-Dolores ^{[13
,16
,17
]}

Ardanaz, Eva ^{[13
,18
,19
]}

Masala, Giovanna ^{[20
]}

Sieri, Sabina ^{[21
]}

Tumino, Rosario ^{[22
]}

Sacerdote, Carlotta ^{[23
]}

Panico, Salvatore ^{[24
]}

May, Anne M. ^{[25
]}

Boden, Stina ^{[26
]}

Gram, Inger T. ^{[27
]}

Skeie, Guri ^{[27
,28
]}

Laouali, Nasser ^{[29
]}

Shah, Sanam ^{[29
]}

Severi, Gianluca ^{[29
,30
]}

Aune, Dagfinn ^{[31
]}

Merritt, Melissa A. ^{[31
,32
]}

Cairat, Manon ^{[33
]}

Weiderpass, Elisabete ^{[34
]}

Riboli, Elio ^{[31
]}

Dossus, Laure ^{[33
]}

Jakszyn, Paula ^{[1
,2
,3
,35
]}

机构：

[1] Bellvitge Biomed Res Inst IDIBELL, Unit Nutr & Canc, Catalan Inst Oncol ICO, Av Granvia 199-203, Barcelona 08908, Spain

[2] Bellvitge Biomed Res Inst IDIBELL, Nutr & Canc Grp, Av Granvia 199-203, Barcelona 08908, Spain

[3] Bellvitge Biomed Res Inst IDIBELL, Epidemiol Publ Hlth Canc Prevent & Palliat Care P, Av Granvia 199-203, Barcelona 08908, Spain

[4] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[5] German Inst Human Nutr Potsdam Rehbruecke DIfE, Nutr Immun & Metab Senior Scientist Grp, Dept Nutr & Gerontol, Nuthetal, Germany

[6] Univ Potsdam, Inst Nutr Sci, Potsdam, Germany

[7] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[8] Danish Canc Soc, Diet Genes & Environm, Res Ctr, Copenhagen, Denmark

[9] Aarhus Univ, Dept Publ Hlth, DK-8000 Aarhus C, Denmark

[10] Publ Hlth Directorate, Asturias, Spain

[11] Escuela Andaluza Salud Publ EASP, Granada, Spain

[12] Inst Invest Biosanitaria Ibs, Granada, Spain

[13] Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain

[14] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain

[15] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, Donostia San Sebastian, Spain

[16] Murcia Reg Hlth Council, Dept Epidemiol, IMIB Arrixaca, Murcia, Spain

[17] Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain

[18] Navarra Publ Hlth Inst, Pamplona, Spain

[19] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[20] Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[21] Fdn IRCCS Ist Nazl Tumori Milano, Epidemiol & Prevent Unit, Milan, Italy

[22] Prov Hlth Author, Canc Registry & Histopathol Dept, Ragusa, Italy

[23] Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Via Santena, Turin, Italy

[24] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[25] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[26] Umea Univ, Dept Radiat Sci, Oncol Unit, Umea, Sweden

[27] Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[28] Univ Leeds, Sch Food Sci & Nutr, Nutr Epidemiol Grp, Leeds, W Yorkshire, England

[29] Paris Saclay Univ, CESP, Exposome & Hered Team, INSERM,Gustave Roussy,UVSQ, F-94805 Villejuif, France

[30] Univ Florence, Dept Stat Comp Sci & Applicat G Parenti, Florence, Italy

[31] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[32] Univ Hawaii, Canc Epidemiol Program, Canc Ctr, Honolulu, HI 96822 USA

[33] Int Agcy Res Canc, Nutr & Metab Sect, Lyon, France

[34] WHO, Int Agcy Res Canc, Director Off, Lyon, France

[35] Ramon Llull Univ, Facuty Hlth Sci Blanquerna, Barcelona, Spain

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2021年 / 36卷 / 09期

基金：

英国医学研究理事会; 瑞典研究理事会;

关键词：

Prospective study; Breast cancer; Inflammatory potential of the diet; Chronic inflammation; INDEX; PATTERNS;

D O I：

10.1007/s10654-021-00772-2

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The role of chronic inflammation on breast cancer (BC) risk remains unclear beyond as an underlying mechanism of obesity and physical activity. We aimed to evaluate the association between the inflammatory potential of the diet and risk of BC overall, according to menopausal status and tumour subtypes. Within the European Prospective Investigation into Cancer and Nutrition cohort, 318,686 women were followed for 14 years, among whom 13,246 incident BC cases were identified. The inflammatory potential of the diet was characterized by an inflammatory score of the diet (ISD). Multivariable Cox regression models were used to assess the potential effect of the ISD on BC risk by means of hazard ratios (HR) and 95% confidence intervals (CI). ISD was positively associated with BC risk. Each increase of one standard deviation (1-Sd) of the score increased by 4% the risk of BC (HR = 1.04; 95% CI 1.01-1.07). Women in the highest quintile of the ISD (indicating a most pro-inflammatory diet) had a 12% increase in risk compared with those in the lowest quintile (HR = 1.12; 95% CI 1.04-1.21) with a significant trend. The association was strongest among premenopausal women, with an 8% increased risk for 1-Sd increase in the score (HR = 1.08; 95% CI 1.01-1.14). The pattern of the association was quite homogeneous by BC subtypes based on hormone receptor status. There were no significant interactions between ISD and body mass index, physical activity, or alcohol consumption. Women consuming more pro-inflammatory diets as measured by ISD are at increased risk for BC, especially premenopausal women.

引用

页码：953 / 964

页数：12

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