The role of dimerisation in the cellular trafficking of G-protein-coupled receptors

被引：84
作者：
Milligan, Graeme [1 ]
机构：
[1] Univ Glasgow, Mol Pharmacol Grp, Fac Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
来源：
CURRENT OPINION IN PHARMACOLOGY | 2010年 / 10卷 / 01期
基金：
英国医学研究理事会; 英国生物技术与生命科学研究理事会;
关键词：
RESONANCE ENERGY-TRANSFER; SECRETIN RECEPTOR; ENDOPLASMIC-RETICULUM; PLASMA-MEMBRANE; PHARMACOLOGICAL CHAPERONES; HETERO-OLIGOMERIZATION; SURFACE DELIVERY; HETERODIMERIZATION; ACTIVATION; HOMODIMERIZATION;
D O I：
10.1016/j.coph.2009.09.010
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The concept that G-protein-coupled receptors can exist as homomeric and/or heteromeric complexes is now well established. Despite this, how dynamic such interactions are and if this may be modulated during receptor trafficking remain topics of debate. Use of endoplasmic reticulum trapping strategies and the generation of asymmetric homomers have started to provide information on the contribution of protein-protein interactions to receptor maturation, cell surface delivery and ligand-mediated endocytosis. Although dimer/oligomer formation appears to be essential for cell surface delivery of class A and class C GPCRs, this may not be the case for class B receptors.
引用
收藏
页码：23 / 29
页数：7
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  • [1] An escort for GPCRs: implications for regulation of receptor density at the cell surface
    Achour, Lamia
    Labbe-Jullie, Catherine
    Scott, Mark G. H.
    Marullo, Stefano
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2008, 29 (10) : 528 - 535
  • [2] Calreticulin enhances B2 bradykinin receptor maturation and heterodimerization
    Alla, Joshua Abd
    Reeck, Kristin
    Langer, Andreas
    Streichert, Thomas
    Quitterer, Ursula
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 387 (01) : 186 - 190
  • [3] HETERO-OLIGOMERIZATION OF CHEMOKINE RECEPTORS
    Appelbe, Shirley
    Milligan, Graeme
    [J]. METHODS IN ENZYMOLOGY, VOL 461: CHEMOKINES, PART B, 2009, 461 : 207 - 225
  • [4] Specificity of olfactory receptor interactions with other G protein-coupled receptors
    Bush, Cristina F.
    Jones, Seth V.
    Lyle, Alicia N.
    Minneman, Kenneth P.
    Ressler, Kerry J.
    Hall, Randy A.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (26) : 19042 - 19051
  • [5] Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective α1b-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers
    Canals, Meritxell
    Lopez-Gimenez, Juan F.
    Milligan, Graeme
    [J]. BIOCHEMICAL JOURNAL, 2009, 417 : 161 - 172
  • [6] The apparent cooperativity of some GPCRs does not necessarily imply dimerization
    Chabre, Marc
    Deterre, Philippe
    Antonny, Bruno
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2009, 30 (04) : 182 - 187
  • [7] Drug development and the cellular quality control system
    Conn, P. Michael
    Janovick, Jo Ann
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2009, 30 (05) : 228 - 233
  • [8] Cell surface targeting of μ-δ opioid receptor heterodirners by RTP4
    Decaillot, Fabien M.
    Rozenfeld, Raphael
    Gupta, Achla
    Devi, Lakshmi A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (41) : 16045 - 16050
  • [9] Regulation of G protein-coupled receptor export trafficking
    Dong, Chunmin
    Filipeanu, Catalin M.
    Duvernay, Matthew T.
    Wu, Guangyu
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2007, 1768 (04): : 853 - 870
  • [10] Enhancement of the surface expression of G protein-coupled receptors
    Dunham, Jill H.
    Hall, Randy A.
    [J]. TRENDS IN BIOTECHNOLOGY, 2009, 27 (09) : 541 - 545
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