Neuronal network models of epileptogenesis

被引:7
作者
Abdullahi, Aminu T. [1 ]
Adamu, Lawan H. [2 ]
机构
[1] Bayero Univ, Fac Basic Med Sci, Dept Psychiat, Kano, Nigeria
[2] Bayero Univ, Fac Basic Med Sci, Aminu Kano Teaching Hosp, Dept Anat, Kano, Nigeria
关键词
ALTERED FUNCTIONAL CONNECTIVITY; IDIOPATHIC GENERALIZED EPILEPSY; JUVENILE MYOCLONIC EPILEPSY; GRAPH-THEORETICAL ANALYSIS; RESTING-STATE NETWORKS; NEUROCOGNITIVE NETWORKS; SMALL-WORLD; FMRI; ABNORMALITIES; PATTERNS;
D O I
10.17712/nsj.2017.2.20160455
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Epilepsy is a chronic neurological condition, following some trigger, transforming a normal brain to one that produces recurrent unprovoked seizures. In the search for the mechanisms that best explain the epileptogenic process, there is a growing body of evidence suggesting that the epilepsies are network level disorders. In this review, we briefly describe the concept of neuronal networks and highlight 2 methods used to analyse such networks. The first method, graph theory, is used to describe general characteristics of a network to facilitate comparison between normal and abnormal networks. The second, dynamic causal modelling, is useful in the analysis of the pathways of seizure spread. We concluded that the end results of the epileptogenic process are best understood as abnormalities of neuronal circuitry and not simply as molecular or cellular abnormalities. The network approach promises to generate new understanding and more targeted treatment of epilepsy.
引用
收藏
页码:85 / 93
页数:9
相关论文
共 75 条
[1]   The system epilepsies: A pathophysiological hypothesis [J].
Avanzini, Giuliano ;
Manganotti, Paolo ;
Meletti, Stefano ;
Moshe, Salomon L. ;
Panzica, Ferruccio ;
Wolf, Peter ;
Capovilla, Giuseppe .
EPILEPSIA, 2012, 53 (05) :771-778
[2]   Neurons that Fire Together Also Conspire Together: Is Normal Sleep Circuitry Hijacked to Generate Epilepsy? [J].
Beenhakker, Mark P. ;
Huguenard, John R. .
NEURON, 2009, 62 (05) :612-632
[3]  
Benuzzi F, 2012, EPILEPSIA, V53, P622, DOI 10.1111/j.1528-1167.2011.03385.x
[4]   Cortical thickness analysis in temporal lobe epilepsy Reproducibility and relation to outcome [J].
Bernhardt, Boris C. ;
Bernasconi, Neda ;
Concha, Luis ;
Bernasconi, Andrea .
NEUROLOGY, 2010, 74 (22) :1776-1784
[5]   Network analysis for a network disorder: The emerging role of graph theory in the study of epilepsy [J].
Bernhardt, Boris C. ;
Bonilha, Leonardo ;
Gross, Donald W. .
EPILEPSY & BEHAVIOR, 2015, 50 :162-170
[6]   Graph-Theoretical Analysis Reveals Disrupted Small-World Organization of Cortical Thickness Correlation Networks in Temporal Lobe Epilepsy [J].
Bernhardt, Boris C. ;
Chen, Zhang ;
He, Yong ;
Evans, Alan C. ;
Bernasconi, Neda .
CEREBRAL CORTEX, 2011, 21 (09) :2147-2157
[7]   Interictal Functional Connectivity of Human Epileptic Networks Assessed by Intracerebral EEG and BOLD Signal Fluctuations [J].
Bettus, Gaelle ;
Ranjeva, Jean-Philippe ;
Wendling, Fabrice ;
Benar, Christian G. ;
Confort-Gouny, Sylviane ;
Regis, Jean ;
Chauvel, Patrick ;
Cozzone, Patrick J. ;
Lemieux, Louis ;
Bartolomei, Fabrice ;
Guye, Maxime .
PLOS ONE, 2011, 6 (05)
[8]   Decreased Basal fMRI Functional Connectivity in Epileptogenic Networks and Contralateral Compensatory Mechanisms [J].
Bettus, Gaelle ;
Guedj, Eric ;
Joyeux, Florian ;
Confort-Gouny, Sylviane ;
Soulier, Elisabeth ;
Laguitton, Virginie ;
Cozzone, Patrick J. ;
Chauvel, Patrick ;
Ranjeva, Jean-Philippe ;
Bartolomei, Fabrice ;
Guye, Maxime .
HUMAN BRAIN MAPPING, 2009, 30 (05) :1580-1591
[9]   Presurgical connectome and postsurgical seizure control in temporal lobe epilepsy [J].
Bonilha, Leonardo ;
Helpern, Joseph A. ;
Sainju, Rup ;
Nesland, Travis ;
Edwards, Jonathan C. ;
Glazier, Steven S. ;
Tabesh, Ali .
NEUROLOGY, 2013, 81 (19) :1704-1710
[10]   Feasibility of simultaneous intracranial EEG-fMRI in humans: A safety study [J].
Carmichael, David W. ;
Thornton, John S. ;
Rodionov, Roman ;
Thornton, Rachel ;
McEvoy, Andrew W. ;
Ordidge, Roger J. ;
Allen, Philip J. ;
Lemieux, Louis .
NEUROIMAGE, 2010, 49 (01) :379-390