Vaginal Microbiota and Sexually Transmitted Infections That May Influence Transmission of Cell-Associated HIV

被引：38

作者：

Cone, Richard A. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Biophys, Baltimore, MD 21210 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2014年 / 210卷

关键词：

polymicrobial microbiota; cell-associated HIV; lactic acid; inflammatory cytokines; HUMAN-IMMUNODEFICIENCY-VIRUS; 2001-2004; NATIONAL-HEALTH; BACTERIAL VAGINOSIS; LACTIC-ACID; GRAM STAIN; TRICHOMONAS-VAGINALIS; FLORA MORPHOLOGY; INCREASED RISK; DISEASE; METAANALYSIS;

D O I：

10.1093/infdis/jiu459

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaginal microbiota and sexually transmitted infections (STIs) are likely to influence the transmission of cell-associated human immunodeficiency virus (HIV). Lactic acid produced by Lactobacillus-dominated microbiota (Nugent score 0-3) will likely inhibit transmission, especially female-to-male transmission. In contrast, polymicrobial microbiota (Nugent score 4-10), community state types IV-A and IV-B, and STIs will likely increase transmission of cell-associated HIV.

引用

页码：S616 / S621

页数：6

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