Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome

被引：131

作者：

Martinez, Jason E. ^{[1
]}

Kahana, Doron D. ^{[1
,2
]}

Ghuman, Simran ^{[1
]}

Wilson, Haley P. ^{[1
]}

Wilson, Julian ^{[1
]}

Kim, Samuel C. J. ^{[1
]}

Lagishetty, Venu ^{[3
,4
]}

Jacobs, Jonathan P. ^{[3
,4
,5
]}

Sinha-Hikim, Amiya P. ^{[1
,2
]}

Friedman, Theodore C. ^{[1
,2
]}

机构：

[1] Charles R Drew Univ Med & Sci, Dept Internal Med, 1621 E 120th St, Los Angeles, CA 90059 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Vatche & Tamar Manoukian,Div Digest Dis, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, UCLA Microbiome Ctr, Los Angeles, CA 90095 USA

[5] Vet Adm Greater Los Angeles Healthcare Syst, Div Gastroenterol Hepatol & Parenteral Nutr, Los Angeles, CA USA

来源：

FRONTIERS IN ENDOCRINOLOGY | 2021年 / 12卷

关键词：

gut microbiome; gut microbiota; gut dysbiosis; nicotine; obesity; high-fat diet; nonalcoholic fatty liver disease; e-cigarette; HIGH-FAT DIET; GLUTEN-FREE DIET; INFLAMMATORY-BOWEL-DISEASE; CENTRAL-NERVOUS-SYSTEM; HEPATIC STEATOSIS; OXIDATIVE STRESS; CARDIORESPIRATORY FITNESS; MEDITERRANEAN DIET; CIGARETTE-SMOKING; ALPHA-SYNUCLEIN;

D O I：

10.3389/fendo.2021.667066

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The study of the intestinal or gut microbiome is a newer field that is rapidly gaining attention. Bidirectional communication between gut microbes and the host can impact numerous biological systems regulating immunity and metabolism to either promote or negatively impact the host's health. Habitual routines, dietary choices, socioeconomic status, education, host genetics, medical care and environmental factors can all contribute to the composition of an individual's microbiome. A key environmental factor that may cause negative outcomes is the consumption of nicotine products. The effects of nicotine on the host can be exacerbated by poor dietary choices and together can impact the composition of the gut microbiota to promote the development of metabolic disease including non-alcoholic fatty liver disease. This review explores the contribution of nicotine, poor dietary choices and other unhealthy lifestyle factors to gut dysbiosis.

引用

页数：13

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