Controlled Release Electrochemical Synthesis and Cytotoxicity Study of Copper(II) Nanoparticles in Copper(II) Decanoate Complex

被引：6

作者：

Nordin, Norazzizi ^{[1
]}

Samad, Wan Zurina ^{[2
]}

Kardia, Egi ^{[3
]}

Yahaya, Badrul Hisham ^{[3
]}

Yusop, Muhammad Rahimi ^{[4
]}

Othman, Mohamed Rozali ^{[4
]}

机构：

[1] Univ Sains Malaysia, Sch Chem Sci, Gelugor 11800, Pulau Pinang, Malaysia

[2] Kuliyyah Sci Int Islamic Univ Malaysia, Dept Chem, Jalan Sultan Ahmad Shah, Kuantan 25200, Pahang, Malaysia

[3] Univ Sains Malaysia, Adv Med & Dent Inst, Regenerat Med Cluster, Kepala Batas 13200, Pulau Pinang, Malaysia

[4] Univ Kebangsaan Malaysia, Fac Sci & Technol, Sch Chem Sci & Food Technol, Ukm Bangi 43600, Selangor, Malaysia

来源：

NANO | 2018年 / 13卷 / 05期

关键词：

Electrochemical synthesis; copper complexes; nanoparticle; cytotoxicity; GREEN SYNTHESIS; CRYSTAL-STRUCTURES; CUO NANOPARTICLES; CARBOXYLATE; SPECTROSCOPY; ACID; COORDINATION; EXTRACT; VOLTAGE; BINDING;

D O I：

10.1142/S1793292018500480

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In the present study, a controlled release electrochemical (CRE) technique based on the controlled release of Cu2+ ion from Cu anode in the presence of decanoic acid (HDe) has been used to synthesize Cu(II) decanoate (CuDe(2)) complex. The effect of applied voltages (1-10 V) and electrolyte concentrations (0.1-2.0M CH3COONH4) during the electrolysis on the nanoparticles obtained was studied using TEM. The results reveal that small-sized nanoparticles (2 +/- 1 nm) were obtained by using lowest applied voltage and CH3COONH4 concentration (1V and 0.1M, respectively). The smallest nanoparticle obtained was then used in the cytotoxicity study against A549 and HeLa cells. The synthesized complex gives moderate cytotoxic effect on the selected cells (IC50 = 15.85 mu M and 20.89 mu M, respectively) and low cytotoxic effect on normal cells (IMR90). Apoptosis is the mode of cell death based on the apoptosis assay that has been conducted.

引用

页数：14

共 55 条

[21] Synthesis of nanoparticles and suspensions by pulsed laser ablation of microparticles in liquid [J].

Kim, Dongsik ;

Jang, Deoksuk .

APPLIED SURFACE SCIENCE, 2007, 253 (19) :8045-8049

[22] Synthesis, crystal structures and spectroscopy of meclofenamic acid and its metal complexes with manganese(II), copper(II), zinc(II) and cadmium(II). Antiproliferative and superoxide dismutase activity [J].

Kovala-Demertzi, Dimitra ;

Staninska, Malgorzata ;

Garcia-Santos, Isabel ;

Castineiras, Alfonso ;

Demertzis, Mavroudis A. .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2011, 105 (09) :1187-1195

[23] Facile synthesis of size-tunable copper and copper oxide nanoparticles using reverse microemulsions [J].

Kumar, Ajeet ;

Saxena, Amit ;

De, Arnab ;

Shankar, Ravi ;

Mozumdar, Subho .

RSC ADVANCES, 2013, 3 (15) :5015-5021

[24]

Lee J, 2006, B KOREAN CHEM SOC, V27, P1869

[25] Characterization, nucleolytic, cytotoxic and antibacterial property of tetrakis(μ-4-chloro-2-nitrobenzoato-κ2O,O′)bis[aquacopper(II)], tetrakis(μ-2-chloro-6-fluorobenzoato-κ2O,O′)bis[aquacopper(II)] and tetrakis(μ-2-chlorobenzoato-κ2O,O′)bis[aquacopper(II)] [J].

Lim, Eng-Khoon ;

Teoh, Siang-Guan ;

Goh, Siu-Mun ;

Ch'ng, Cynn-Dee ;

Ng, Chew-Hee ;

Fun, Hoong-Kun ;

Rosli, Mohd Mustaclim ;

Najimudin, Nazalan ;

Beh, Hooi-Kheng ;

Seow, Lay-Jing ;

Ismail, Norhayati ;

Ismail, Zhari ;

Asmawi, Mohd Zaini ;

Cheah, Yew-Hoong .

POLYHEDRON, 2009, 28 (07) :1320-1330

[26] Introduction: Nanoparticles in Medicine [J].

Lin, Wenbin .

CHEMICAL REVIEWS, 2015, 115 (19) :10407-10409

[27] Electrochemical methods - important means for fabrication of fluorescent nanoparticles [J].

Long, Yan-Min ;

Zhao, Qiao-Ling ;

Zhang, Zhi-Ling ;

Tian, Zhi-Quan ;

Pang, Dai-Wen .

ANALYST, 2012, 137 (04) :805-815

[28] Two water-soluble copper(II) complexes: Synthesis, characterization, DNA cleavage, protein binding activities and in vitro anticancer activity studies [J].

Lu, Jing ;

Sun, Qian ;

Li, Jun-Ling ;

Jiang, Lin ;

Gu, Wen ;

Liu, Xin ;

Tian, Jin-Lei ;

Yan, Shi-Ping .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2014, 137 :46-56

[29] Copper Complexes as Anticancer Agents [J].

Marzano, Cristina ;

Pellei, Maura ;

Tisato, Francesco ;

Santini, Carlo .

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2009, 9 (02) :185-211

[30] Interaction of methotrexate, an anticancer agent, with copper(II) ions: coordination pattern, DNA-cleaving properties and cytotoxic studies [J].

Nagaj, Justyna ;

Kolkowska, Paulina ;

Bykowska, Aleksandra ;

Komarnicka, Urszula K. ;

Kyziol, Agnieszka ;

Jezowska-Bojczuk, Malgorzata .

MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (01) :115-123

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