Persistent HIV Type 1 Seronegative Status Is Associated With Lower CD8+ T-Cell Activation

被引：9

作者：

Kuebler, Peter J. ^{[1
]}

Mehrotra, Megha L. ^{[3
]}

Shaw, Brian I. ^{[1
]}

Leadabrand, Kaitlyn S. ^{[1
]}

Milush, Jeffrey M. ^{[1
]}

York, Vanessa A. ^{[1
]}

Defechereux, Patricia ^{[3
]}

Grant, Robert M. ^{[2
,3
]}

Kallas, Esper G. ^{[5
]}

Nixon, Douglas F. ^{[4
]}

机构：

[1] Univ Calif San Francisco, Div Expt Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[3] Gladstone Inst, Gladstone Inst Virol & Immunol, San Francisco, CA USA

[4] George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC USA

[5] Univ Sao Paulo, Div Clin Immunol & Allergy, BR-05508 Sao Paulo, Brazil

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 213卷 / 04期

基金：

美国国家卫生研究院; 巴西圣保罗研究基金会;

关键词：

HIV-1; T-cell activation; HESN; infection risk; IMMUNE ACTIVATION; INFECTION; SUSCEPTIBILITY; PREDICTS; WOMEN; SEX;

D O I：

10.1093/infdis/jiv425

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We leveraged data from the Preexposure Prophylaxis Initiative (iPrEx), a global trial of preexposure chemoprophylaxis against human immunodeficiency virus type 1 (HIV-1) infection, to compare T-cell activation between those who remained negative for HIV-1 and those who became infected during the trial. The frequency of CD38(+)HLA-DR(+)CD8(+)T cells was greater in those who seroconverted, relative to the frequency in those who remained uninfected (1.30% vs 0.82%, respectively; P = .005). This translated to an odds ratio of 4.26 (95% confidence interval, 1.54-11.78) for the association between CD8(+)T-cell activation and infection with HIV-1. T-cell activation may be a biomarker for elevated HIV-1 infection risk.

引用

页码：569 / 573

页数：5

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