Omega-3 polyunsaturated fatty acids have beneficial effects on visceral fat in diet-induced obesity model

被引：9

作者：

de Mello, Aline Haas ^{[1
]}

Schraiber, Rosiane de Bona ^{[1
]}

de Souza Goldim, Mariana Pereira ^{[1
]}

Mathias, Khiany ^{[1
]}

Mendes, Carolini ^{[2
]}

Anastacio Borges Correa, Maria Eduarda ^{[2
]}

Gomes, Maria Luiza ^{[3
]}

Lock Silveira, Paulo Cesar ^{[2
]}

Schuck, Patricia Fernanda ^{[4
]}

Petronilho, Fabricia ^{[1
]}

Rezin, Gislaine Tezza ^{[1
]}

机构：

[1] Univ Sul Santa Catarina, Programa Posgrad Ciencias Saude, Lab Neurobiol Proc Inflamatorios & Metab, Tubarao, SC, Brazil

[2] Univ Extremo Sul Catarinense, Programa Posgrad Ciencias Saude, Lab Fisiopatol Expt, Criciuma, SC, Brazil

[3] Univ Extremo Sul Catarinense, Programa Posgrad Ciencias Saude, Lab Erros Inatos Metab, Criciuma, SC, Brazil

[4] Pontificia Univ Catolica Rio Grande do Sul, Escola Ciencias, Lab Erros Inatos Metab, Porto Alegre, RS, Brazil

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 2019年 / 97卷 / 06期

关键词：

obesity; visceral fat; omega-3; PUFAs; oxidative stress; energy metabolism; OXIDATIVE STRESS; ADIPOSE-TISSUE; FISH-OIL; INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION; SKELETAL-MUSCLE; INFLAMMATION; OMEGA-3-FATTY-ACIDS; MICE; METABOLISM;

D O I：

10.1139/bcb-2018-0361

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study evaluated the effects of omega-3 polyunsaturated fatty acids (PUFAs) on oxidative stress and energy metabolism parameters in the visceral fat of a high-fat-diet induced obesity model. Energy intake, body mass, and visceral fat mass were also evaluated. Male Swiss mice received either a control diet (control group) or a high-fat diet (obese group) for 6 weeks. After this period, the groups were divided into control + saline, control + omega-3, obese + saline, and obese + omega-3, and to these groups 400 mg.(kg body mass)(-1).day(-1) of fish oil (or saline) was administered orally, for 4 weeks. Energy intake and body mass were monitored throughout the experiment. In the 10th week, the animals were euthanized and the visceral fat (mesenteric) was removed. Treatment with omega-3 PUFAs did not affect energy intake or body mass, but it did reduced visceral fat mass. In visceral fat, omega-3 PUFAs reduced oxidative damage and alleviated changes to the antioxidant defense system and the Krebs cycle. The mitochondrial respiratory chain was neither altered by obesity nor by omega-3 PUFAs. In conclusion, omega-3 PUFAs have beneficial effects on the visceral fat of obese mice because they mitigate changes caused by the consumption of a high-fat diet.

引用

页码：693 / 701

页数：9