Early post-stressor intervention with minocycline, a second-generation tetracycline, attenuates post-traumatic stress response in an animal model of PTSD

被引:57
作者
Levkovitz, Yechiel [1 ,4 ]
Fenchel, Daphna [1 ,4 ]
Kaplan, Zeev [2 ]
Zohar, Joseph [3 ,4 ]
Cohen, Hagit [2 ]
机构
[1] Beer Yaakov Mental Hlth Ctr, Beer Yaagov, Israel
[2] Ben Gurion Univ Negev, Fac Hlth Sci, Minist Hlth, Beer Sheva Mental Hlth Ctr,Anxiety & Stress Res U, IL-84105 Beer Sheva, Israel
[3] Chaim Sheba Med Ctr, Minist Hlth, Div Psychiat, IL-52621 Tel Hashomer, Israel
[4] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
关键词
Animal model; Post-traumatic stress disorder; Minocycline; Interleukin-1 (IL-1); Interleukin-6 (IL-6); Tumor necrosis factor-alpha (TNF-alpha); PSYCHOLOGICAL STRESS; IMMUNE-SYSTEM; BRAIN; MICROGLIA; DISORDER; ABNORMALITIES; INFLAMMATION; EXPRESSION; PLASTICITY; INCREASES;
D O I
10.1016/j.euroneuro.2014.11.012
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We assessed the effects of minocycline, a tetracycline with anti-inflammatory, anti-apoptotic and neuroprotective capacities, in an animal model of post-traumatic stress disorder (PTSD). Rats were exposed to psychogenic stress and treated 1 h later with minocycline or saline. Behavioral measures included the elevated plus-maze (EPM) and acoustic startle response (ASR) 7 days post stress-exposure. One day after behavioral testing, animals were exposed to a trauma cue and freezing response was assessed. Local levels of cytokines interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-alpha) in the hippocampus, frontal cortex (FC) and hypothalamus were then examined. Minocycline attenuated anxious-like behaviors in stress-exposed rats. In addition, decreased levels of cytokines were measured in exposed rats treated with minocycline compared to their counterparts treated with saline. This study suggests a potential use of minocycline in preventing physiological and behavioral alternations resulting from acute exposure to psychological stress. As this is the first study to report beneficial outcomes for minocycline treatment in an animal model of PTSD, further investigations of the use of minocycline in stress-related conditions with emphasis on PTSD is needed. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.
引用
收藏
页码:124 / 132
页数:9
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