Immobilization of asymmetric multifunctional catalysts on an insoluble polymer

被引：76
作者：
Matsunaga, S [1 ]
Ohshima, T [1 ]
Shibasaki, M [1 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 44期
基金：
日本学术振兴会;
关键词：
asymmetric catalyst; asymmetric synthesis; solid-phase synthesis; Michael reaction; linked-BINOL;
D O I：
10.1016/S0040-4039(00)01486-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Polymer-supported linked-BINOL was synthesized to immobilize asymmetric catalysts with two BINOL units. The advantage of the polymer-supported linked-BINOL over randomly polymer-supported BINOL was confirmed by asymmetric Michael reaction. A novel polymer-supported La-Zn-linked-BINOL complex afforded the Michael adduct in good yield and moderate ee. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：8473 / 8478
页数：6
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