Neuropeptides and Langerhans cells

被引：30
作者：
Lambert, RW [1 ]
Granstein, RD [1 ]
机构：
[1] Cornell Univ, Coll Med, Dept Dermatol, New York, NY 10021 USA
来源：
EXPERIMENTAL DERMATOLOGY | 1998年 / 7卷 / 2-3期
关键词：
Langerhans cells; neuropeptides; calcitonin gene related peptide; vasoactive intestinal peptide; substance P;
D O I：
10.1111/j.1600-0625.1998.tb00306.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The immune system and nervous system are intimately related. In addition to neuroendocrine mechanisms, neuropeptides have a variety of effects on immune cells and are responsible at least in part for neurogenic inflammation, The presence of neuropeptides in the skin has been well documented. The influence of neuropeptides on Langerhans cells is the focus of this paper. The physical presence and effects of calcitonin gene-related peptide on Langerhans cells is emphasized. Discussion also includes the putative inflammatory and immunologic roles of vasoactive intestinal peptide, substance P, neurotensin, neuropeptide Y, and somatostatin in the skin.
引用
收藏
页码：73 / 80
页数：8
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