Microenvironment of Liver Regeneration in Liver Cancer

被引:32
作者
Li Han-min [1 ,2 ,3 ]
Ye Zhi-hua [1 ,2 ,3 ]
机构
[1] Hubei Univ Chinese Med, Inst Applicat Fdn, Hubei Prov Hosp Tradit Chinese Med, Affiliated Hosp, Wuhan 430061, Hubei, Peoples R China
[2] Hubei Univ Chinese Med, Inst Liver Dis, Hubei Prov Hosp Tradit Chinese Med, Affiliated Hosp, Wuhan 430061, Hubei, Peoples R China
[3] Hubei Prov Acad Tradit Chinese Med, Wuhan 430074, Hubei, Peoples R China
基金
中国国家自然科学基金;
关键词
liver regeneration microenvironment; liver cancer; tonifying Shen (Kidney) to regulate liver regeneration and repair by affecting stem cells and their microenvironment; EPITHELIAL-MESENCHYMAL TRANSITION; HEPATOCELLULAR-CARCINOMA; TGF-BETA; MET; HGF; PROGNOSIS; CELLS;
D O I
10.1007/s11655-017-2806-0
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
The occurrence and development of liver cancer are essentially the most serious outcomes of uncontrolled liver regeneration. The progression of liver cancer is inevitably related to the abnormal microenvironment of liver regeneration. The deterioration observed in the microenvironment of liver regeneration is a necessary condition for the occurrence, development and metastasis of cancer. Therefore, the use of a technique to prevent and treat liver cancer via changes in the microenvironment of liver regeneration is a novel strategy. This strategy would be an effective way to delay, prevent or even reverse cancer occurrence, development and metastasis through an improvement in the liver regeneration microenvironment along with the integrated regulation of multiple components, targets, levels, channels and time sequences. In addition, the treatment of "tonifying Shen (Kidney) to regulate liver regeneration and repair by affecting stem cells and their microenvironment" can regulate "the dynamic imbalance between the normal liver regeneration and the abnormal liver regeneration"; this would improve the microenvironment of liver regeneration, which is also a mechanism by which liver cancer may be prevented or treated.
引用
收藏
页码:555 / 560
页数:6
相关论文
共 50 条
  • [1] Microenvironment of Liver Regeneration in Liver Cancer
    LI Han-min
    YE Zhi-hua
    Chinese Journal of Integrative Medicine, 2017, 23 (07) : 555 - 560
  • [2] Microenvironment of liver regeneration in liver cancer
    Han-min Li
    Zhi-hua Ye
    Chinese Journal of Integrative Medicine, 2017, 23 : 555 - 560
  • [3] Microcirculation of liver cancer, microenvironment of liver regeneration, and the strategy of Chinese medicine
    Li Han-min
    CHINESE JOURNAL OF INTEGRATIVE MEDICINE, 2016, 22 (03) : 163 - 167
  • [4] Microcirculation of Liver Cancer,Microenvironment of Liver Regeneration,and the Strategy of Chinese Medicine
    李瀚旻
    Chinese Journal of Integrative Medicine , 2016, (03) : 163 - 167
  • [5] Microcirculation of liver cancer, microenvironment of liver regeneration, and the strategy of Chinese medicine
    Han-min Li
    Chinese Journal of Integrative Medicine, 2016, 22 : 163 - 167
  • [6] Immunotherapy in liver cancer: overcoming the tolerogenic liver microenvironment
    Liu, Yanju
    Yang, Hongyuan
    Li, Tian
    Zhang, Na
    FRONTIERS IN IMMUNOLOGY, 2024, 15
  • [7] Targeting the mechano-microenvironment and liver cancer stem cells: a promising therapeutic strategy for liver cancer
    Fu, Xiaorong
    Zhang, Yi
    Luo, Qing
    Ju, Yang
    Song, Guanbin
    CANCER BIOLOGY & MEDICINE, 2023, 20 (11) : 816 - 829
  • [8] Deciphering the heterogeneity and plasticity of the tumor microenvironment in liver cancer provides insights for prognosis
    Sun, Yihao
    Shi, Guojuan
    Yang, Jian
    Zhou, Chun-Zhong
    Peng, Chuhan
    Luo, Yu-Hong
    Pan, Ying
    Wang, Rui-Qi
    FRONTIERS IN PHARMACOLOGY, 2025, 16
  • [9] Editorial: The tumor microenvironment and malignant properties in primary liver cancer
    Qu, Chen
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [10] Metabolic reprogramming in the tumor microenvironment of liver cancer
    Lin, Jian
    Rao, Dongning
    Zhang, Mao
    Gao, Qiang
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2024, 17 (01)