Coumarins from Galipea panamensis and Their Activity against Leishmania panamensis

被引：50

作者：

Arango, Victor ^{[1
]}

Robledo, Sara ^{[2
]}

Seon-Meniel, Blandine ^{[3
]}

Figadere, Bruno ^{[1
,3
]}

Cardona, Wilson ^{[1
]}

Saez, Jairo ^{[1
]}

Otalvaro, Felipe ^{[4
]}

机构：

[1] Univ Antioquia, Inst Quim, Medellin 1226, Colombia

[2] Univ Antioquia, PECET, Medellin 1226, Colombia

[3] Univ Paris Sud, Lab Pharmacognosie, CNRS BIOCIS, F-92296 Chatenay Malabry, France

[4] Univ Antioquia, Inst Quim Sintesis & Biosintesis Metab Nat, Medellin 1226, Colombia

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 05期

关键词：

QUINOLINE ALKALOIDS; RUTACEAE; CHEMOTHERAPY; PHEBALOSIN; BOLIVIA; PLANT;

D O I：

10.1021/np100146y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new coumarin compounds (1 and 2), phebalosin (3), its derived artifact murralongin (4), and murrangatin acetonide (5) were isolated from the leaves of Galipea panamensis. The structures of 1 and 2 were assigned as 7-{[(2R*)-3,3-dimethyloxiran-2-yl]methoxy}-8-R2R*,3R*)-3-isopropenyloxiran-2-yl]-2H-chromen-2-one and 7-methoxy-8-(4-methyl-3-furyl)-2H-chromen-2-one, respectively, on the basis of their spectroscopic data (primarily NMR and MS). Compounds 1-3 were tested against axenic amastigote forms of Leishmania panamensis and displayed 50% effective concentrations (EC50) of 9.9, 10.5, and 14.1 mu g/mL, respectively. These three compounds also displayed cytotoxicity (IC50) at concentrations of 9.7, 33.0, and 20.7 mu g/mL, respectively, on human promonocytic U-937 cells.

引用

页码：1012 / 1014

页数：3

共 23 条

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