Combination ACE inhibitors and angiotensin II receptor blockers for hypertension

被引：11

作者：

Finnegan, PM ^{[1
]}

Gleason, BL ^{[1
]}

机构：

[1] St Louis Coll Pharm, Div Pharm Practice, St Louis, MO 63110 USA

来源：

ANNALS OF PHARMACOTHERAPY | 2003年 / 37卷 / 06期

关键词：

angiotensin-converting enzyme inhibitor; angiotensin II receptor blocker; hypertension;

D O I：

10.1345/aph.1C393

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

OBJECTIVE: To review data concerning combined angiotensin-converting enzyme (ACE) inhibitor and angiotensin 11 receptor blocker (ARB) therapy for hypertension. DATA SOURCES: MEDLINE (1966-April 2003), IPA (1970-April 2003), and EMBASE (1974-April 2003) with search terms of ACE inhibitor, angiotensin receptor blocker, essential hypertension, and combination therapy. DATA SYNTHESIS: ACE inhibitors provide incomplete blockade of the renin-angiotensin system, sometimes leading to loss of blood pressure control. Addition of ARBs may in theory further reduce blood pressure. Studies of combined ACE inhibitor and ARB therapy for managing hypertension were evaluated. CONCLUSIONS: While studies have shown statistically significant blood pressure reductions with ACE/ARB combination therapy, clinical significance is lacking. Further trials are needed before routine use of the combination can be recommended.

引用

页码：886 / 889

页数：4

共 19 条

[1]

[Anonymous], 1997, ARCH INTERN MED, V157, P2413, DOI DOI 10.1001/ARCHINTE.1997.00440420033005

[2]

[Anonymous], 2002, Diabetes care, V25, pS1

[3] Pilot study of combined blockade of the renin-angiotensin system in essential hypertensive patients [J].

Azizi, M ;

Linhart, A ;

Alexander, J ;

Goldberg, A ;

Menten, J ;

Sweet, C ;

Ménard, J .

JOURNAL OF HYPERTENSION, 2000, 18 (08) :1139-1147

[4] Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy [J].

Brenner, BM ;

Cooper, ME ;

de Zeeuw, D ;

Keane, WF ;

Mitch, WE ;

Parving, HH ;

Remuzzi, G ;

Snapinn, SM ;

Zhang, ZX ;

Shahinfar, S .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (12) :861-869

[5] A randomized trial of the angiotensin-receptor blocker valsartan in chronic heart failure [J].

Cohn, JN ;

Tognoni, G .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (23) :1667-1675

[6] MULTIPLE PATHWAYS OF ANGIOTENSIN PRODUCTION IN THE BLOOD-VESSEL WALL - EVIDENCE, POSSIBILITIES AND HYPOTHESES [J].

DZAU, VJ .

JOURNAL OF HYPERTENSION, 1989, 7 (12) :933-936

[7] Therapeutic implications of escape from angiotensin-converting enzyme inhibition in patients with chronic heart failure [J].

Ennezat P.V. ;

Berlowitz M. ;

Sonnenblick E.H. ;

Le Jemtel T.H. .

Current Cardiology Reports, 2000, 2 (3) :258-262

[8] Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects [J].

Gainer, JV ;

Morrow, JD ;

Loveland, A ;

King, DJ ;

Brown, NJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (18) :1285-1292

[9]

HUNT SA, 2001, ACC AHA GUIDELINES E

[10] Dual blockade of the renin-angiotensin system in type 1 patients with diabetic nephropathy [J].

Jacobsen, P ;

Andersen, S ;

Rossing, K ;

Hansen, BV ;

Parving, HH .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2002, 17 (06) :1019-1024

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