One-Pot Sequential N-Heterocyclic Carbene/Rhodium(III) Catalysis: Synthesis of Fused Polycyclic Isocoumarins

被引：37
作者：
Youn, So Won [1 ,2 ]
Yoo, Huen Ji [1 ,2 ]
机构：
[1] Hanyang Univ, Dept Chem, Ctr New Direct Organ Synth, Seoul 04763, South Korea
[2] Hanyang Univ, Inst Mat Design, Seoul 04763, South Korea
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 13期
基金：
新加坡国家研究基金会;
关键词：
benzo-fused lactones; C-H activation; one-pot sequential catalysis; organocatalysis; rhodium catalysis; C-H ACTIVATION; OXIDATIVE CYCLIZATION; DUAL CATALYSIS; BENZOIC-ACIDS; REGIOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; AROMATIC-ALDEHYDES; BOND ALKENYLATIONS; CARBOXYLIC-ACIDS; NATURAL-PRODUCTS;
D O I：
10.1002/adsc.201700072
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A one-pot sequential N-heterocyclic carbene-rhodium (NHC-Rh) catalysis is described, demonstrating the compatibility of NHC and Rh catalysts. N-Heterocyclic carbene-catalyzed aerobic oxidation of benzaldehydes and subsequent rhodium(III)-catalyzed oxidative coupling/ annulation with multiple bonds enabled the formation of two C-O bonds and one C-C bond in a single pot. This operationally easy, one-pot protocol under air provides access to a diverse array of valuable fused polycyclic isocoumarins.
引用
收藏
页码：2176 / 2183
页数：8
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