A role for FGF2 in visceral adiposity-associated mammary epithelial transformation

被引：15

作者：

Benham, Vanessa ^{[1
]}

Chakraborty, Debrup ^{[1
]}

Bullard, Blair ^{[1
]}

Bernard, Jamie J. ^{[1
]}

机构：

[1] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA

来源：

ADIPOCYTE | 2018年 / 7卷 / 02期

关键词：

Obesity; cancer; FGF2; adiposity; visceral fat; breast; breast cancer; BREAST-CANCER RISK; GROWTH-FACTOR RECEPTOR; BODY-MASS INDEX; WAIST CIRCUMFERENCE; THERAPEUTIC TARGET; OBESITY PHENOTYPES; FACTOR FAMILY; CELLS; TISSUE; PROLIFERATION;

D O I：

10.1080/21623945.2018.1445889

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is a leading risk factor for post-menopausal breast cancer, and this is concerning as 40% of cancer diagnoses in 2014 were associated with overweight/obesity. Despite this epidemiological link, the underlying mechanism responsible is unknown. We recently published that visceral adipose tissue (VAT) releases FGF2 and stimulates the transformation of skin epithelial cells. Furthermore, obesity is differentially associated with many epithelial cancers, and this mechanistic link could be translational. As FGF2 and FGFR1 are implicated in breast cancer progression, we hypothesize that VAT-derived FGF2 plays a translational role in promoting adiposity-associated mammary epithelial cell transformation. In this brief report, data suggest that FGF2/FGFR1 signaling is a potential mechanistic link in VAT-stimulated transformation of breast epithelial cells.

引用

页码：113 / 120

页数：8

共 56 条

[41] Angiogenesis Markers Quantification in Breast Cancer and Their Correlation with Clinicopathological Prognostic Variables [J].

Rykala, Jan ;

Przybylowska, Karolina ;

Majsterek, Ireneusz ;

Pasz-Walczak, Grazyna ;

Sygut, Andrzej ;

Dziki, Adam ;

Kruk-Jeromin, Julia .

PATHOLOGY & ONCOLOGY RESEARCH, 2011, 17 (04) :809-817

[42] Biomarkers associated with breast cancer are associated with obesity [J].

Sauter, Edward R. ;

Scott, Stephen ;

Hewett, John ;

Kliethermes, Beth ;

Ruhlen, Rachel L. ;

Basarakodu, Krishnamohan ;

de la Torre, Roger .

CANCER DETECTION AND PREVENTION, 2008, 32 (02) :149-155

[43] Mechanisms of Disease:: adipokines and breast cancer -: endocrine and paracrine mechanisms that connect adiposity and breast cancer [J].

Schaeffler, Andreas ;

Schoelmerich, Juergen ;

Buechler, Christa .

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM, 2007, 3 (04) :345-354

[44]

SCHAPIRA DV, 1994, CANCER, V74, P632, DOI 10.1002/1097-0142(19940715)74:2<632::AID-CNCR2820740215>3.0.CO

[45]

2-T

[46] Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis [J].

Shaw, KRM ;

Wrobel, CN ;

Brugge, JS .

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2004, 9 (04) :297-310

[47] Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study [J].

Slattery, Martha L. ;

John, Esther M. ;

Stern, Mariana C. ;

Herrick, Jennifer ;

Lundgreen, Abbie ;

Giuliano, Anna R. ;

Hines, Lisa ;

Baumgartner, Kathy B. ;

Torres-Mejia, Gabriela ;

Wolff, Roger K. .

BREAST CANCER RESEARCH AND TREATMENT, 2013, 140 (03) :587-601

[48] FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer [J].

Turner, Nicholas ;

Pearson, Alex ;

Sharpe, Rachel ;

Lambros, Maryou ;

Geyer, Felipe ;

Lopez-Garcia, Maria A. ;

Natrajan, Rachael ;

Marchio, Caterina ;

Iorns, Elizabeth ;

Mackay, Alan ;

Gillett, Cheryl ;

Grigoriadis, Anita ;

Tutt, Andrew ;

Reis-Filho, Jorge S. ;

Ashworth, Alan .

CANCER RESEARCH, 2010, 70 (05) :2085-2094

[49] The antiapoptotic effect of fibroblast growth factor-2 is mediated through nuclear factor-κB activation induced via interaction between Akt and IκB kinase-β in breast cancer cells [J].

Vandermoere, F ;

El Yazidi-Belkoura, I ;

Adriaenssens, E ;

Lemoine, J ;

Hondermarck, H .

ONCOGENE, 2005, 24 (35) :5482-5491

[50] Adipose tissue and breast epithelial cells: A dangerous dynamic duo in breast cancer [J].

Wang, Yuan-Yuan ;

Lehuede, Camille ;

Laurent, Victor ;

Dirat, Beatrice ;

Dauvillier, Stephanie ;

Bochet, Ludivine ;

Le Gonidec, Sophie ;

Escourrou, Ghislaine ;

Valet, Philippe ;

Muller, Catherine .

CANCER LETTERS, 2012, 324 (02) :142-151

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