A role for FGF2 in visceral adiposity-associated mammary epithelial transformation

被引：15

作者：

Benham, Vanessa ^{[1
]}

Chakraborty, Debrup ^{[1
]}

Bullard, Blair ^{[1
]}

Bernard, Jamie J. ^{[1
]}

机构：

[1] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA

来源：

ADIPOCYTE | 2018年 / 7卷 / 02期

关键词：

Obesity; cancer; FGF2; adiposity; visceral fat; breast; breast cancer; BREAST-CANCER RISK; GROWTH-FACTOR RECEPTOR; BODY-MASS INDEX; WAIST CIRCUMFERENCE; THERAPEUTIC TARGET; OBESITY PHENOTYPES; FACTOR FAMILY; CELLS; TISSUE; PROLIFERATION;

D O I：

10.1080/21623945.2018.1445889

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is a leading risk factor for post-menopausal breast cancer, and this is concerning as 40% of cancer diagnoses in 2014 were associated with overweight/obesity. Despite this epidemiological link, the underlying mechanism responsible is unknown. We recently published that visceral adipose tissue (VAT) releases FGF2 and stimulates the transformation of skin epithelial cells. Furthermore, obesity is differentially associated with many epithelial cancers, and this mechanistic link could be translational. As FGF2 and FGFR1 are implicated in breast cancer progression, we hypothesize that VAT-derived FGF2 plays a translational role in promoting adiposity-associated mammary epithelial cell transformation. In this brief report, data suggest that FGF2/FGFR1 signaling is a potential mechanistic link in VAT-stimulated transformation of breast epithelial cells.

引用

页码：113 / 120

页数：8

共 56 条

[1] FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium [J].

Agarwal, D. ;

Pineda, S. ;

Michailidou, K. ;

Herranz, J. ;

Pita, G. ;

Moreno, L. T. ;

Alonso, M. R. ;

Dennis, J. ;

Wang, Q. ;

Bolla, M. K. ;

Meyer, K. B. ;

Menendez-Rodriguez, P. ;

Hardisson, D. ;

Mendiola, M. ;

Gonzalez-Neira, A. ;

Lindblom, A. ;

Margolin, S. ;

Swerdlow, A. ;

Ashworth, A. ;

Orr, N. ;

Jones, M. ;

Matsuo, K. ;

Ito, H. ;

Iwata, H. ;

Kondo, N. ;

Hartman, M. ;

Hui, M. ;

Lim, W. Y. ;

Iau, P. T-C ;

Sawyer, E. ;

Tomlinson, I. ;

Kerin, M. ;

Miller, N. ;

Kang, D. ;

Choi, J-Y ;

Park, S. K. ;

Noh, D-Y ;

Hopper, J. L. ;

Schmidt, D. F. ;

Makalic, E. ;

Southey, M. C. ;

Teo, S. H. ;

Yip, C. H. ;

Sivanandan, K. ;

Tay, W-T ;

Brauch, H. ;

Bruening, T. ;

Hamann, U. ;

Dunning, A. M. ;

Shah, M. .

BRITISH JOURNAL OF CANCER, 2014, 110 (04) :1088-1100

[2] Adiposity, adult weight change, and postmenopausal breast cancer risk [J].

Ahn, Jiyoung ;

Schatzkin, Arthur ;

Lacey, James V., Jr. ;

Albanes, Demetrius ;

Ballard-Barbash, Rachel ;

Adams, Kenneth F. ;

Kipnis, Victor ;

Mouw, Traci ;

Hollenbeck, Albert R. ;

Leitzmann, Michael F. .

ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (19) :2091-2102

[3] Carcinogenesis in mouse and human cells: parallels and paradoxes [J].

Balmain, A ;

Harris, CC .

CARCINOGENESIS, 2000, 21 (03) :371-377

[4] The FGF/FGF receptor axis as a therapeutic target in breast cancer [J].

Brady, Nicholas J. ;

Chuntova, Pavlina ;

Bade, Lindsey K. ;

Schwertfeger, Kathryn L. .

EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM, 2013, 8 (04) :391-402

[5] Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer [J].

Chakraborty, D. ;

Benham, V. ;

Bullard, B. ;

Kearney, T. ;

Hsia, H. C. ;

Gibbon, D. ;

Demireva, E. Y. ;

Lunt, S. Y. ;

Bernard, J. J. .

ONCOGENE, 2017, 36 (48) :6668-6679

[6] Prevention of Skin Carcinogenesis by the β-Blocker Carvedilol [J].

Chang, Andy ;

Yeung, Steven ;

Thakkar, Arvind ;

Huang, Kevin M. ;

Liu, Mandy M. ;

Kanassatega, Rhye-Samuel ;

Parsa, Cyrus ;

Orlando, Robert ;

Jackson, Edwin K. ;

Andresen, Bradley T. ;

Huang, Ying .

CANCER PREVENTION RESEARCH, 2015, 8 (01) :31-40

[7] A meta-analysis of published literature on waist-to-hip ratio and risk of breast cancer [J].

Connolly, BS ;

Barnett, C ;

Vogt, KN ;

Li, T ;

Stone, J ;

Boyd, NF .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2002, 44 (02) :127-138

[8] FGFR1 amplification in breast carcinomas:: a chromogenic in situ hybridisation analysis [J].

Elsheikh, Somaia Elbauomy ;

Green, Andrew R. ;

Lambros, Maryou B. K. ;

Turner, Nicholas C. ;

Grainge, Matthew J. ;

Powe, Des ;

Ellis, Ian O. ;

Reis-Filho, Jorge S. .

BREAST CANCER RESEARCH, 2007, 9 (02)

[9] Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes [J].

Esser, Nathalie ;

Legrand-Poels, Sylvie ;

Piette, Jacques ;

Scheen, Andre J. ;

Paquot, Nicolas .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2014, 105 (02) :141-150

[10] Depot-specific expression of fibroblast growth factors in human adipose tissue [J].

Gabrielsson, BG ;

Johansson, JM ;

Jennische, E ;

Jernås, M ;

Itoh, Y ;

Peltonen, M ;

Olbers, T ;

Lönn, L ;

Lönroth, H ;

Sjöström, L ;

Carlsson, B ;

Carlsson, LMS ;

Lönn, M .

OBESITY RESEARCH, 2002, 10 (07) :608-616

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