Increased UCP1 expression in the perirenal adipose tissue of patients with renal cell carcinoma

被引：13
作者：
Li, Xueqin [1 ]
Wang, Gongcheng [2 ]
Liu, Juan [3 ]
Ding, Guoxian [3 ]
机构：
[1] Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Dept Gerontol, Huaian 223300, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Dept Urol, Huaian 223300, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Hosp Affiliated 1, Dept Geriatr Endocrinol, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China
来源：
ONCOLOGY REPORTS | 2019年 / 42卷 / 05期
基金：
中国国家自然科学基金;
关键词：
uncoupling protein 1; perirenal adipose tissue; brown adipose tissue; renal cell carcinoma; BODY-MASS INDEX; FAT INFILTRATION; TUMOR SIZE; BROWN FAT; CANCER; ADIPOCYTES; ENERGY; METASTASIS; METABOLISM; CACHEXIA;
D O I：
10.3892/or.2019.7306
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Perirenal adipose tissue (PAT) has been implicated in renal cell carcinoma (RCC). The expression of uncoupling protein 1 (UCP1) is higher in PAT compared with that in back subcutaneous adipose tissue (bSAT). The aim of the present study was to determine UCP1 expression in different parts of PAT and to analyze the correlation between UCP1 expression in PAT and RCC. PAT from the upper and lower renal poles and bSAT samples were collected from 50 patients with RCC (RCC group) and 54 patients with renal cysts (control group) who had undergone renal surgery. Both UCP1 mRNA and protein levels were found to be significantly higher and adipocytes appeared to be smaller in the PAT of the RCC group. Furthermore, the RCC group had more multilocular UCP1-positive adipocytes. UCP1 staining in the PAT was significantly stronger in the RCC group, but there was no significant difference in UCP1 staining in the bSAT between the two groups. Furthermore, Fuhrman grade and T stage were higher in the high UCP1 expression group of RCC patients. In conclusion, high UCP1 expression in the PAT may serve as an indicator of poor prognosis in RCC.
引用
收藏
页码：1972 / 1980
页数：9
相关论文
共 35 条
[1]   Body size and renal cell cancer incidence in a large US cohort study [J].
Adams, Kenneth F. ;
Leitzmann, Michael F. ;
Albanes, Demetrius ;
Kipnis, Victor ;
Moore, Steven C. ;
Schatzkin, Arthur ;
Chow, Wong-Ho .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2008, 168 (03) :268-277
[2]   Perinephric and renal sinus fat infiltration in pT3a renal cell carcinoma: possible prognostic differences [J].
Bedke, Jens ;
Buse, Stephan ;
Pritsch, Maria ;
Macher-Goeppinger, Stephan ;
Schirmacher, Peter ;
Haferkamp, Axel ;
Hohenfellner, Markus .
BJU INTERNATIONAL, 2009, 103 (10) :1349-1354
[3]   INCREASED BROWN ADIPOSE-TISSUE ACTIVITY IN CHILDREN WITH MALIGNANT DISEASE [J].
BIANCHI, A ;
BRUCE, J ;
COOPER, AL ;
CHILDS, C ;
KOHLI, M ;
MORRIS, ID ;
MORRISJONES, P ;
ROTHWELL, NJ .
HORMONE AND METABOLIC RESEARCH, 1989, 21 (11) :640-641
[4]   Brown adipose tissue: Function and physiological significance [J].
Cannon, B ;
Nedergaard, J .
PHYSIOLOGICAL REVIEWS, 2004, 84 (01) :277-359
[5]   Identification and Importance of Brown Adipose Tissue in Adult Humans. [J].
Cypess, Aaron M. ;
Lehman, Sanaz ;
Williams, Gethin ;
Tal, Ilan ;
Rodman, Dean ;
Goldfine, Allison B. ;
Kuo, Frank C. ;
Palmer, Edwin L. ;
Tseng, Yu-Hua ;
Doria, Alessandro ;
Kolodny, Gerald M. ;
Kahn, C. Ronald .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (15) :1509-1517
[6]   Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion [J].
Dirat, Beatrice ;
Bochet, Ludivine ;
Dabek, Marta ;
Daviaud, Daniele ;
Dauvillier, Stephanie ;
Majed, Bilal ;
Wang, Yuan Yuan ;
Meulle, Aline ;
Salles, Bernard ;
Le Gonidec, Sophie ;
Garrido, Ignacio ;
Escourrou, Ghislaine ;
Valet, Philippe ;
Muller, Catherine .
CANCER RESEARCH, 2011, 71 (07) :2455-2465
[7]   Obesity, Cholesterol, and Clear-Cell Renal Cell Carcinoma (RCC) [J].
Drabkin, Harry A. ;
Gemmill, Robert M. .
ADVANCES IN CANCER RESEARCH, VOL 107, 2010, 107 :39-56
[8]   Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 [J].
Ferlay, Jacques ;
Shin, Hai-Rim ;
Bray, Freddie ;
Forman, David ;
Mathers, Colin ;
Parkin, Donald Maxwell .
INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (12) :2893-2917
[9]   TNF-α Induces Epithelial-Mesenchymal Transition of Renal Cell Carcinoma Cells via a GSK3β-Dependent Mechanism [J].
Ho, Ming-Yi ;
Tang, Shye-Jye ;
Chuang, Mei-Jen ;
Cha, Tai-Lung ;
Li, Jing-Yao ;
Sun, Guang-Huan ;
Sun, Kuang-Hui .
MOLECULAR CANCER RESEARCH, 2012, 10 (08) :1109-1119
[10]   PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer [J].
Kir, Serkan ;
Komaba, Hirotaka ;
Garcia, Ana P. ;
Economopoulos, Konstantinos P. ;
Liu, Wei ;
Lanske, Beate ;
Hodin, Richard A. ;
Spiegelman, Bruce M. .
CELL METABOLISM, 2016, 23 (02) :315-323
1234