The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse

被引：27

作者：

Cheng, Xiao-Rui ^{[1
]}

Zhou, Wen-Xia ^{[1
]}

Zhang, Yong-Xiang ^{[1
]}

机构：

[1] Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China

来源：

FITOTERAPIA | 2007年 / 78卷 / 03期

基金：

中国国家自然科学基金;

关键词：

learning and memory; Alzheimer's disease; cDNA microarray; Liuwei Dihuang decoction (LW); gene target;

D O I：

10.1016/j.fitote.2006.11.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Liuwei Dilmang decoction (LW), a traditional Chinese medicinal prescription, enhances the cognitive function of CNS by significant modulating effects on some of the gene expressions. Expressions of genes, such as DUSP12, NSF, STUB1, CaMKII alpha, AMFR, UQCRFS1 and other 11 novel genes without any functional clues changed significantly. These genes are involved in the protein-tyrosine phosphatase family, the AAA (ATPases associat,ed with diverse cellular activities) gene family, the serine/threonine protein kinases family, ubiquitin ligase, mitochondrial function and so on. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：175 / 181

页数：7

共 36 条

[1]

ALLAN BD, 2005, EXP GERONTOL, V40, P774

[2]

Banks WA, 2001, J PHARMACOL EXP THER, V297, P1113

[3] Cholinergic markers in Alzheimer disease [J].

Bartus, RT ;

Emerich, DF .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (23) :2208-2208

[4]

CHENG XR, 2006, NEUROBIOL AGING 0325

[5] The pharmacogenomics of Alzheimer's disease [J].

Crentsil, V .

AGEING RESEARCH REVIEWS, 2004, 3 (02) :153-169

[6] Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease [J].

Eckert, A ;

Keil, U ;

Marques, CA ;

Bonert, A ;

Frey, C ;

Schüssel, K ;

Müller, WE .

BIOCHEMICAL PHARMACOLOGY, 2003, 66 (08) :1627-1634

[7]

GEORGEHYSLOP ST, 2000, ANN NY ACAD SCI, V924, P1

[8] An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP) [J].

He, B ;

Bai, SX ;

Hnat, AT ;

Kalman, RI ;

Minges, JT ;

Patterson, C ;

Wilson, EM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (29) :30643-30653

[9]

HOI JS, 2004, BIOCHEM BIOPH RES CO, V321, P574

[10] Genotype and phenotype in Alzheimer's disease [J].

Holmes, C .

BRITISH JOURNAL OF PSYCHIATRY, 2002, 180 :131-134

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