Factors associated with relative muscle strength in patients with type 2 diabetes mellitus

被引:8
作者
Chen, Chiao-Nan [1 ]
Chen, Ting-Chung [1 ]
Tsai, Shiow-Chwen [2 ]
Hwu, Chii-Min [3 ,4 ]
机构
[1] Natl Yang Ming Chiao Tung Univ, Sch Biomed Sci & Engn, Dept Phys Therapy & Assist Technol, Taipei, Taiwan
[2] Univ Taipei, Inst Sports Sci, Taipei, Taiwan
[3] Taipei Vet Gen Hosp, Dept Med, Sect Endocrinol & Metab, 201 Shi Pai Rd,Sec 2,Chung Cheng Build 11F,Room 5, Taipei 112, Taiwan
[4] Natl Yang Ming Chiao Tung Univ, Sch Med, Fac Med, Taipei, Taiwan
关键词
Inflammation; T2DM; Muscle strength; INSULIN-RESISTANCE; SKELETAL-MUSCLE; NATIONAL-HEALTH; ADIPOSE-TISSUE; OLDER-ADULTS; SARCOPENIA; QUALITY; RISK; MASS; INFLAMMATION;
D O I
10.1016/j.archger.2021.104384
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objectives: Some patients with type 2 diabetes mellitus (T2DM) experience decreased mobility associated with lower relative muscle strength (normalized with muscle mass). This study aimed to identify factors predicting relative muscle strength of patients with T2DM assessed at regular clinical visits. Methods: A total of 144 T2DM patients underwent fasting blood drawing (determining white blood cell count [WBC], diabetic kidney disease [DKD], and glycated hemoglobin [HbA1c]) and the assessment of body composition, diabetic peripheral neuropathy (DPN), activity level, and muscle strength (grip, knee extensor, and ankle plantar flexor strength). One-way ANOVA and multiple regression models were used to identify factors associated with the relative muscle strength. Results: Our data showed that age, diabetes duration, fat percentage, WBC, DPN, and DKD were negatively associated with the relative muscle strength. Specifically, a greater WBC was associated with lower relative muscle strength of both distal and proximal muscle groups of extremities after the adjustment of other associated factors. DPN was associated with lower relative strength of the distal muscle groups of extremities. Conclusions: WBC may be used as a marker of inflammation, and greater count, even within the normal range, is negatively associated with the relative muscle strength in patients with T2DM.
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页数:8
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