Effects of Curcuma spp. on P-glycoprotein function

被引：36

作者：

Ampasavate, Chadarat ^{[2
]}

Sotanaphun, Uthai ^{[3
]}

Phattanawasin, Panadda ^{[4
]}

Piyapolrungroj, Nusara ^{[1
]}

机构：

[1] Silpakorn Univ, Dept Biopharm, Fac Pharm, Nakhon Pathom, Thailand

[2] Chiang Mai Univ, Dept Pharmaceut Sci, Fac Pharm, Chiang Mai 50000, Thailand

[3] Silpakorn Univ, Dept Pharmacognosy, Nakhon Pathom, Thailand

[4] Silpakorn Univ, Dept Pharmaceut Chem, Nakhon Pathom, Thailand

来源：

PHYTOMEDICINE | 2010年 / 17卷 / 07期

关键词：

Curcuma longa; Curcuma sp "Khamin-oi; Curcuminoids; P-glycoprotein; MEDIATED TRANSPORT; CACO-2; CELLS; EXPRESSION; MODULATION; EFFLUX; GP; FLAVONOIDS; DIGOXIN;

D O I：

10.1016/j.phymed.2009.09.004

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effects of Curcuma longa (khamin chan) and Curcuma sp. "khamin-oi" (khamin-oi), as well as isolated major curcuminoids on intestinal P-gp functions were evaluated in vitro. The accumulation of R123 in Caco-2 cells was increased and the R123 efflux ratios were significantly decreased by both Curcuma longa and Curcuma sp. "khamin-oi" extracts, indicating their roles on efflux transporters. The a-b transport of daunorubicin was increased by curcumin, demethoxycurcumin and bisdemethoxycurcumin while the b-a transport was significantly decreased by curcumin and demethoxycurcumin. However, calcein-AM uptake into the human P-gp overexpression cell line, LLC-GA5-COL300, was increased by curcumin and demethoxycurcumin in a concentration-dependent manner but not affected by bisdemethoxycurcumin. These results show that curcumin and demethoxycurcumin could inhibit P-gp but bisdemethoxycurcumin may modulate the function of other efflux transporters such as MRP. Taken together, the information may indicate the impact of Curcuma longa and Curcuma sp. "khamin-oi" on pharmacokinetics of orally administered drugs that are P-gp substrates. (C) 2009 Elsevier GmbH. All rights reserved.

引用

页码：506 / 512

页数：7

共 27 条

[1] P-glycoprotein (P-gp) mediated efflux in Caco-2 cell monolayers: The influence of culturing conditions and drug exposure on P-gp expression levels [J].