Na+/H+ exchange and hypoxic pulmonary hypertension

被引：18

作者：

Huetsch, John ^{[1
]}

Shimoda, Larissa A. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, Baltimore, MD 21224 USA

来源：

PULMONARY CIRCULATION | 2015年 / 5卷 / 02期

基金：

美国国家卫生研究院;

关键词：

hypoxia; pulmonary vascular smooth muscle; intracellular pH; SMOOTH-MUSCLE-CELLS; SODIUM-HYDROGEN-EXCHANGE; PROTEIN-KINASE-C; ENDOTHELIN-RECEPTOR ANTAGONIST; INTRACELLULAR PH REGULATION; RED-BLOOD-CELLS; ARTERIAL-HYPERTENSION; MOLECULAR-CLONING; MYOCARDIAL-INFARCTION; GROWTH-FACTORS;

D O I：

10.1086/680213

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Intracellular pH (pHi) homeostasis is key to the functioning of vascular smooth muscle cells, including pulmonary artery smooth muscle cells (PASMCs). Sodium-hydrogen exchange (NHE) is an important contributor to pHi control in PASMCs. In this review, we examine the role of NHE in PASMC function, in both physiologic and pathologic conditions. In particular, we focus on the contribution of NHE to the PASMC response to hypoxia, considering both acute hypoxic pulmonary vasoconstriction and the development of pulmonary vascular remodeling and pulmonary hypertension in response to chronic hypoxia. Hypoxic pulmonary hypertension remains a disease with limited therapeutic options. Thus, this review explores past efforts at disrupting NHE signaling and discusses the therapeutic potential that such efforts may have in the field of pulmonary hypertension.

引用

页码：228 / 243

页数：16

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