Human Papillomavirus-Associated Oropharyngeal High-Grade Neuroendocrine Carcinoma in an Adolescent: Case Report and Review of Literature

被引:4
作者
Sinno, Sara [1 ]
Assaad, Adel M. [2 ]
Shabb, Nina Salem [1 ]
机构
[1] Amer Univ Beirut, Med Ctr, Dept Pathol & Lab Med, Cairo St,3rd Floor, Beirut 110236, Lebanon
[2] Virginia Mason Med Ctr, Dept Pathol, Seattle, WA 98101 USA
关键词
Oropharynx; small cell carcinoma; squamous cell carcinoma; human papillomavirus; pediatric; SQUAMOUS-CELL CARCINOMA; P16; IMMUNOHISTOCHEMISTRY; HEAD; CANCER; OVEREXPRESSION; TRANSMISSION; INFECTIONS; PREVALENCE; DNA;
D O I
10.1177/1179556519870520
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Oropharyngeal small cell carcinomas (OPSmCC) are rare with only few case reports and case series published in the literature. More recently. an association of these tumors with human papillomavirus (HPV) infection has been detected. However, unlike oropharyngeal squamous cell carcinomas which have a better outcome when associated with HPV. OPSmCC exhibit an aggressive behavior. In this article, we report a case of tonsillar carcinoma arising in a 14-year-old boy that was associated with HPV infection. The tumor exhibited morphologic features of small cell carcinoma with no overt squamous differentiation. Yet, by immunohistochemistry, it showed diffuse and strong co-expression of both squamous and neuroendocrine markers. In addition. we present the clinicopathologic features of all the cases of OPSmCC reported in the literature for which p16 and/or HPV testing have been done.
引用
收藏
页数:7
相关论文
共 26 条
[1]   p16 overexpression in high-grade neuroendocrine carcinomas of the head and neck: potential diagnostic pitfall with HPV-related carcinomas [J].
Alos, Llucia ;
Hakim, Sofia ;
Larque, Ana-Belen ;
de la Oliva, Jorge ;
Rodriguez-Carunchio, Leonardo ;
Caballero, Miguel ;
Nadal, Alfons ;
Marti, Carles ;
Guimera, Nuria ;
Fernandez-Figueras, Maria-Teresa ;
Quint, Wim ;
Ordi, Jaume .
VIRCHOWS ARCHIV, 2016, 469 (03) :277-284
[2]   Small Cell Neuroendocrine Carcinoma of the Oropharynx Harbouring Oncogenic HPV-Infection [J].
Bates T. ;
McQueen A. ;
Iqbal M.S. ;
Kelly C. ;
Robinson M. .
Head and Neck Pathology, 2014, 8 (1) :127-131
[3]   Human Papillomavirus-Related Small Cell Carcinoma of the Oropharynx [J].
Bishop, Justin A. ;
Westra, William H. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2011, 35 (11) :1679-1684
[4]  
Bonomi Marcelo, 2017, Cancers Head Neck, V2, P3, DOI 10.1186/s41199-017-0022-4
[5]   Prevalence of human papillomavirus type 16 DNA in squamous cell carcinoma of the palatine tonsil, and not the oral cavity, in young patients - A distinct clinicopathologic and molecular disease entity [J].
El-Mofty, SK ;
Lu, DW .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2003, 27 (11) :1463-1470
[6]   Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial [J].
Fakhry, Carole ;
Westra, William H. ;
Cmelak, Sigui Li Anthony ;
Ridge, John A. ;
Pinto, Harlan ;
Forastiere, Arlene ;
Gillison, Maura L. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (04) :261-269
[7]   Tonsillar Small Cell Carcinoma: Potential Contribution of Human Papillomavirus [J].
Fecher, Roger A. ;
Leader, Brittany A. ;
Patil, Yash ;
Butler, Randall .
AMERICAN JOURNAL OF CASE REPORTS, 2018, 19 :482-485
[8]   Evidence for a causal association between human papillomavirus and a subset of head and neck cancers [J].
Gillison, ML ;
Koch, WM ;
Capone, RB ;
Spafford, M ;
Westra, WH ;
Wu, L ;
Zahurak, ML ;
Daniel, RW ;
Viglione, M ;
Symer, DE ;
Shah, KV ;
Sidransky, D .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (09) :709-720
[9]   Small cell neuroendocrine carcinomas of the lung do not harbor high-risk human papillomavirus [J].
Hartley, Christopher P. ;
Steinmetz, Heather B. ;
Memoli, Vincent A. ;
Tafe, Laura J. .
HUMAN PATHOLOGY, 2015, 46 (04) :577-582
[10]   A robust response to combination immune checkpoint inhibitor therapy in HPV-related small cell cancer: a case report [J].
Ho, Won Jin ;
Rooper, Lisa ;
Sagorsky, Sarah ;
Kang, Hyunseok .
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2018, 6