A convenient microwave-assisted synthesis of N-glycosyl amino acids

被引：33
|
作者：
Paolini, Aria
Nuti, Francesca
de la Cruz Pozo-Carrero, Maria
Barbetti, Francesca
Kolesinska, Beata
Kaminski, Zbigniew J.
Chelli, Mario
Papini, Anna M.
机构：
[1] Univ Florence, Dipartimento Chim Organ, Lab Peptide & Prot Chem & Biol, I-50019 Sesto Fiorentino, FI, Italy
[2] CNR, ICCOM, I-50019 Sesto Fiorentino, FI, Italy
[3] Tech Univ Lodz, Inst Organ Chem, PL-90924 Lodz, Poland
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 16期
关键词：
microwave-assisted synthesis; N-glycosyl amino acids; synthetic glycopeptide probe; coupling reagent; solid-phase peptide synthesis;
D O I：
10.1016/j.tetlet.2007.02.087
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Optimization of coupling reactions of glycosylamines with Fmoc-protected aspartic acid, by microwave approach, is described. Different reaction conditions, quantities of substrates and solvents were tested to develop simple and reproducible methodologies. The best results were obtained using new triazine-based coupling reagents with a monomode microwave Discover (R) BenchMate (TM) instrument (CEM). The N-glycosyl amino acids were then deprotected to achieve final products for SPPS. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2901 / 2904
页数：4
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