Preparation and Sustained-Release Property of Triblock Copolymer/Calcium Phosphate Nanocomposite as Nanocarrier for Hydrophobic Drug

被引：38
作者：
Cao, Shao-Wen [1 ,2 ]
Zhu, Ying-Jie [1 ,2 ]
Wu, Jin [1 ,2 ]
Wang, Ke-Wei [1 ,2 ]
Tang, Qi-Li [1 ,2 ]
机构：
[1] Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Shanghai 200050, Peoples R China
来源：
NANOSCALE RESEARCH LETTERS | 2010年 / 5卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Nanocomposite; P123; Calcium phosphate; Hydrophobic drug; Sustained release; BLOCK-COPOLYMER; GENE DELIVERY; NONVIRAL VECTORS; NANOPARTICLES; MICELLES; P123; PARTICLES; MOLECULES; CELLS;
D O I：
10.1007/s11671-010-9558-5
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The P123/ACP nanocomposite with sizes less than 100 nm consisting of triblock copolymer P123 and amorphous calcium phosphate (ACP) has been prepared by using an aqueous solution containing CaCl2, (NH4)(3)PO4, and P123 at room temperature. The P123/ACP nanocomposite is used as the nanocarrier for hydrophobic drug ibuprofen, based on the combined advantages of both amphiphilic block copolymer and calcium phosphate delivery system. The P123/ACP nanocomposite has a much higher ibuprofen loading capacity (148 mg/g) than the single-phase calcium phosphate nanostructures. The drug release percentage of the P123/ACP nanocomposite in simulated body fluid reaches about 100% in a period of 156 h, which is much slower than that of single-phase calcium phosphate nanostructures. It is expected that the P123/ACP nanocomposite is promising for the application in the controlled delivery of hydrophobic drugs.
引用
收藏
页码：781 / 785
页数：5
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