Trends in Antimicrobial Resistance of Acinetobacter baumannii Isolates from a Metropolitan Detroit Health System

被引：64

作者：

Reddy, Tara ^{[1
]}

Chopra, Teena ^{[1
]}

Marchaim, Dror ^{[1
]}

Pogue, Jason M. ^{[2
]}

Alangaden, George ^{[1
]}

Salimnia, Hossein ^{[3
]}

Boikov, Dina ^{[3
]}

Navon-Venezia, Shiri ^{[4
]}

Akins, Robert ^{[3
]}

Selman, Philip ^{[3
]}

Dhar, Sorabh ^{[1
]}

Kaye, Keith S. ^{[1
]}

机构：

[1] Wayne State Univ, Div Infect Dis, Detroit Med Ctr, Detroit, MI USA

[2] Wayne State Univ, Dept Pharm Serv, Sinai Grace Hosp, Detroit Med Ctr, Detroit, MI USA

[3] Detroit Med Ctr, Dept Clin Microbiol, Detroit, MI USA

[4] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Div Epidemiol, Sackler Sch Med, IL-69978 Tel Aviv, Israel

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 05期

关键词：

FIELD GEL-ELECTROPHORESIS; PSEUDOMONAS-AERUGINOSA; INFECTIONS; TIGECYCLINE; COLISTIN; EMERGENCE; PATHOGENS; OUTBREAK; IMPACT; SAFETY;

D O I：

10.1128/AAC.01665-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A phenotypic and genotypic analysis of Acinetobacter baumannii was conducted from 2003 to 2008 in Detroit, MI. The incidence of A. baumannii increased from 1.7 to 3.7/1,000 patient days during the study period. Susceptibility to ampicillin-sulbactam and imipenem decreased from similar to 90% to similar to 40%. Genotyping revealed polyclonality, suggesting either emergence of multiple resistant strains or spread of a common genetic element. The sharp rise mandates major multidisciplinary interventions to optimize management of this multidrugresistant pathogen.

引用

页码：2235 / 2238

页数：4

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