Synthesis and characterization of Arabic gum capped gold nanoparticles for tumor-targeted drug delivery

被引：39

作者：

Devi, P. Renuga ^{[1
,2
]}

Kumar, C. Senthil ^{[2
]}

Selvamani, P. ^{[1
,2
]}

Subramanian, N. ^{[1
,2
]}

Ruckmani, K. ^{[1
,2
]}

机构：

[1] Anna Univ, Natl Facil Drug Dev Acad Pharmaceut & Allied Ind, Tiruchirappalli 620024, Tamil Nadu, India

[2] Anna Univ, Dept Pharmaceut Technol, Tiruchirappalli 620024, Tamil Nadu, India

来源：

MATERIALS LETTERS | 2015年 / 139卷

关键词：

Green synthesis; Gold Nanoparticles; Vitex negundo; Epirubicin; FTIR; Cancer; GREEN SYNTHESIS; LEAF EXTRACT; BIOSYNTHESIS; SILVER;

D O I：

10.1016/j.matlet.2014.10.010

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In this study, green synthesis of gold nanoparticles (GNPs) was achieved by sunlight-mediated method using the leaves extract of Vitex negundo (V. negundo) as a reducing agent and Arabic gum is used as a capping agent. Epirubicin-loaded Arabic gum-capped gold nanoparticles (E-GNPs) was synthesized and then functionalized with folic acid for tumor-targeted drug delivery. Folic acid-functionalized (Fa-E-GNPs) nanoparticles were characterized by different physicochemical characterization methods such as UV spectra, FESEM, particle size analysis, zeta potential, SAED and HRTEM. In vitro stability of the Fa-E-GNPs was also analyzed. The Fa-E-GNPs showed enhanced cytotoxic effects on lung adenocarcinoma (A549) cell line, suggesting that the folic acid functionalization led to cancer cell targeting and in turn increased the uptake of epirubicin by cancer cells. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：241 / 244

页数：4

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