Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction

被引：28

作者：

Zhong, Hai-Jing ^{[1
]}

Lee, Bo Ra ^{[3
]}

Boyle, Joshua William ^{[3
]}

Wang, Wanhe ^{[2
]}

Ma, Dik-Lung ^{[2
]}

Chan, Philip Wai Hong ^{[3
,4
]}

Leung, Chung-Hang ^{[1
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China

[2] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China

[3] Monash Univ, Sch Chem, Clayton, Vic 3800, Australia

[4] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 34期

基金：

中国国家自然科学基金; 澳大利亚研究理事会;

关键词：

HISTONE MODIFICATIONS; LEUKEMIA; PROTEINS; DISCOVERY; FAMILY; CANCER; GENES; SET1;

D O I：

10.1039/c6cc01079b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The natural product-like compound 1 was identified as a direct inhibitor of the menin-MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.

引用

页码：5788 / 5791

页数：4

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