Immunomodulating Properties of Humic Acids Extracted from Oligotrophic Sphagnum magellanicum Peat

被引：7
作者：
Trofimova, E. S. [1 ]
Zykova, M., V [2 ]
Danilets, M. G. [1 ]
Ligacheva, A. A. [1 ]
Sherstoboev, E. Yu [1 ]
Tsupko, A., V [2 ]
Mikhalyov, D. A. [2 ]
Belousov, M., V [2 ]
机构：
[1] Russian Acad Sci, Tomsk Natl Res Med Ctr, ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk, Russia
[2] Siberian State Med Univ, Minist Hlth Russian Federat, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2021年 / 170卷 / 04期
基金：
俄罗斯科学基金会;
关键词：
humic acids; cytokines; humoral immune response; peritoneal macrophages; mononuclear cells; TNF-ALPHA; ACTIVATION;
D O I：
10.1007/s10517-021-05088-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Humic acids extracted with sodium pyrophosphate from Oligotrophic Sphagnum magellanicum peat reduce mitogen-stimulated production of anti-inflammatory cytokine IL-10 by mouse peritoneal macrophages and do not affect the secretion of IL-4 by lymphocytes. The studied humic acid sample stimulates the production of proinflammatory cytokines IL-12, TNF alpha, IL-1 beta, and IFN gamma by immunocompetent mouse cells and human mononuclear cells. Course administration of humic acids to mice enhances the humoral immunity, increasing the number of antibody-forming cells in the spleen and the titer of antibodies in the blood serum after immunization with sheep red blood cells.
引用
收藏
页码：461 / 465
页数：5
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