Expression patterns of WNT/β-CATENIN signaling molecules during human tooth development

被引：53

作者：

Wang, Bingmei ^{[1
]}

Li, Hanliang ^{[1
]}

Liu, Ying ^{[1
]}

Lin, Xin ^{[1
]}

Lin, Yao ^{[1
]}

Wang, Ye ^{[1
]}

Hu, Xuefeng ^{[1
]}

Zhang, Yanding ^{[1
]}

机构：

[1] Fujian Normal Univ, Coll Life Sci, Fujian Key Lab Dev & Neuro Biol, Fuzhou 350108, Fujian, Peoples R China

来源：

JOURNAL OF MOLECULAR HISTOLOGY | 2014年 / 45卷 / 05期

关键词：

WNT/beta-CATENIN signaling; Human tooth germ; Gene expression; Transcriptional factors; Growth factors; ADENOID CYSTIC CARCINOMA; EPITHELIAL-MESENCHYMAL INTERACTIONS; DEVELOPING MOUSE TOOTH; BETA-CATENIN; ADENOMATOUS POLYPOSIS; MUTATION; WNT5A; PATHWAY; GENES; DIFFERENTIATION;

D O I：

10.1007/s10735-014-9572-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The WNT/beta-CATENIN signaling has been demonstrated to play critical roles in mouse tooth development, but little is known about the status of these molecules in human embryonic tooth. In this study, expression patterns of WNT/beta-CATENIN signaling components, including WNT ligands (WNT3, WNT5A), receptors (FZD4, FZD6, LRP5), transducers (beta-CATENIN), transcription factors (TCF4, LEF1) and antagonists (DKK1, SOSTDC1) were investigated in human tooth germ at the bud, cap and bell stages by in situ hybridization. All these genes exhibited similar but slightly distinct expression patterns in human tooth germ in comparison with mouse. Furthermore the mRNA expression of these genes in incisors and molars at the bell stage was also examined by real-time PCR. Our results reveal the status of active WNT/beta-CATENIN signaling in the human tooth germ and suggest these components may also play an essential role in the regulation of human tooth development.

引用

页码：487 / 496

页数：10

共 45 条

[31] Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family [J].