Formation of Synthetically Versatile 2-Aminobenzophenones from Readily Accessed Acyl Hydrazides

被引：4

作者：

Ahmed, Nehaal ^{[1
]}

Shamsabadi, Andre ^{[1
]}

Chudasama, Vijay ^{[1
]}

机构：

[1] UCL, Dept Chem, 20 Gordon St, London WC1H 0AJ, England

来源：

ACS OMEGA | 2019年 / 4卷 / 27期

基金：

英国工程与自然科学研究理事会;

关键词：

CATALYZED DIRECT ADDITION; ONE-POT PROCEDURE; POLYSUBSTITUTED QUINOLINES; QUINAZOLINE DERIVATIVES; EFFICIENT SYNTHESIS; FACILE; CONVERSION; ALDEHYDES; ESTERS; ACIDS;

D O I：

10.1021/acsomega.9b03417

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report the transformation of readily accessed acyl hydrazides into protected 2-aminobenzophenones via a two-step process involving an aryne-based molecular rearrangement followed by a one-pot addition-elimination procedure. The assembly of the scaffold is tolerant of a wide variety of functional groups, and the carbamate group on the product can be facilely removed to afford highly valuable 2-aminobenzophenones. Application of the protocol was demonstrated in the synthesis of neurological medicine phenazepam.

引用

页码：22601 / 22612

页数：12

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