3D Cell Culture Models in COVID-19 Times: A Review of 3D Technologies to Understand and Accelerate Therapeutic Drug Discovery

被引：16

作者：

de Dios-Figueroa, Guadalupe Tonantzin ^{[1
]}

Aguilera-Marquez, Janette del Rocio ^{[1
]}

Camacho-Villegas, Tanya A. ^{[2
]}

Lugo-Fabres, Pavel H. ^{[2
]}

机构：

[1] Ctr Invest & Asistencia Tecnol & Diseno Estado Ja, Dept Med & Pharmaceut Biotechnol, Ave Normalistas 800, Guadalajara 44270, Jalisco, Mexico

[2] CONACYT, Ctr Invest & Asistencia Tecnol & Diseno Estado Ja, Dept Med & Pharmaceut Biotechnol, Ave Normalistas 800, Guadalajara 44270, Jalisco, Mexico

来源：

BIOMEDICINES | 2021年 / 9卷 / 06期

关键词：

3D cell culture models; SARS-CoV-2; organoids; antiviral therapeutic drug discovery; EPITHELIAL RAFT CULTURES; ANIMAL-MODELS; VIRUS-INFECTION; VIRAL DISEASES; SARS-COV-2; CHALLENGES; GROWTH; SPHEROIDS; PLATFORM; MATRIX;

D O I：

10.3390/biomedicines9060602

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the last decades, emerging viruses have become a worldwide concern. The fast and extensive spread of the disease caused by SARS-CoV-2 (COVID-19) has impacted the economy and human activity worldwide, highlighting the human vulnerability to infectious diseases and the need to develop and optimize technologies to tackle them. The three-dimensional (3D) cell culture models emulate major tissue characteristics such as the in vivo virus-host interactions. These systems may help to generate a quick response to confront new viruses, establish a reliable evaluation of the pathophysiology, and contribute to therapeutic drug evaluation in pandemic situations such as the one that humanity is living through today. This review describes different types of 3D cell culture models, such as spheroids, scaffolds, organoids, and organs-on-a-chip, that are used in virus research, including those used to understand the new severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2).

引用

页数：19

共 127 条

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