Commensal flora triggered target anti-inflammation of alginate-curcumin micelle for ulcerative colitis treatment

被引：38

作者：

Wang, Yanan ^{[1
,2
]}

Li, Yanan ^{[1
,2
]}

He, Lingyun ^{[1
,2
]}

Mao, Baiping ^{[1
,2
]}

Chen, Sian ^{[1
,2
]}

Martinez, Vanessa ^{[3
]}

Guo, Xiaoling ^{[1
,2
]}

Shen, Xian ^{[1
,2
]}

Liu, Baohua ^{[1
,2
]}

Li, Chao ^{[1
,2
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 2, 109 Xueyuan West Rd, Wenzhou 325027, Peoples R China

[2] Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuan West Rd, Wenzhou 325027, Peoples R China

[3] Univ St Thomas, Houston Methodist Res Inst, 3800 Montrose Blvd, Houston, TX 77006 USA

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2021年 / 203卷

基金：

中国国家自然科学基金;

关键词：

Curcumin-alginate esterification; Micelle; Anti-inflammation; Ulcerative colitis; Target release; COLON-SPECIFIC PRODRUG; DRUG-DELIVERY; 5-AMINOSALICYLIC ACID; NANOPARTICLES; RELEASE; DOXORUBICIN; METABOLISM; ESTER;

D O I：

10.1016/j.colsurfb.2021.111756

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Ulcerative colitis (UC) is a chronic, idiopathic inflammatory bowel disease characterized by dysregulation of colon immune response. Curcumin (Cur) has strong anti-inflammatory activities, but the application is severely hindered by the extremely hydrophobicity and pitiful bioavailability. Alginate (Alg), a natural polysaccharide with ideal solubility and biosafety, was introduced to prepare the esterified alginate-curcumin conjugate (AlgCur) and constructed stable Alg-Cur micelle in physiological solutions. Compared with crystalline Cur, the target anti-inflammatory activities of Alg-Cur were systematically investigated. The results showed that Alg-Cur exerted effective anti-inflammatory effects in Raw 264.7 cells. After oral administration, 92.32 % of Alg-Cur reached colon, and the ester bonds were quickly sheared by abundant esterase produced by commensal anaerobic flora. The released Cur was quickly absorbed in-situ in monomolecular state, and effectively ameliorated the colonic inflammation and tissue damage by inhibiting the TLR4 expression in colonic epithelial cell, reducing the transcription and expression of the pro-inflammation cytokines downstream, as well as the infiltration of lymphocytes, macrophages and neutrophils. The Alg-Cur micelle effectively enhanced the hydrophilicity and bioavailability of Cur, and the commensal flora triggered Cur release showed great potential for UC treatment.

引用

页数：12

共 54 条

[51] Biodegradable Polymer-Curcumin Conjugate Micelles Enhance the Loading and Delivery of Low-Potency Curcumin [J].

Yang, Rulei ;

Zhang, Suai ;

Kong, Deling ;

Gao, Xuli ;

Zhao, Yanjun ;

Wang, Zheng .

PHARMACEUTICAL RESEARCH, 2012, 29 (12) :3512-3525

[52] Discovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents [J].

Zhang, Yali ;

Zhao, Chengguang ;

He, Wenfei ;

Wang, Zhe ;

Fang, Qilu ;

Xiao, Bing ;

Liu, Zhiguo ;

Liang, Guang ;

Yang, Shulin .

DRUG DESIGN DEVELOPMENT AND THERAPY, 2014, 8 :373-382

[53] Nanozyme-mediated catalytic nanotherapy for inflammatory bowel disease [J].

Zhao, Jiulong ;

Gao, Wei ;

Cai, Xiaojun ;

Xu, Jiajia ;

Zou, Duowu ;

Li, Zhaoshen ;

Hu, Bing ;

Zheng, Yuanyi .

THERANOSTICS, 2019, 9 (10) :2843-2855

[54] Structural features underlying recognition and translocation of extracellular polysaccharides [J].

Zimmer, Jochen .

INTERFACE FOCUS, 2019, 9 (02)

← 1 2 3 4 5 6 →