Cooperative Lewis Acid/Cp*CoIII Catalyzed C-H Bond Activation for the Synthesis of Isoquinolin-3-ones

被引：166
作者：
Kim, Ju Hyun [1 ]
Gressies, Steffen [1 ]
Glorius, Frank [1 ]
机构：
[1] Univ Munster, Inst Organ Chem, Corrensstr 40, D-48149 Munster, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 18期
关键词：
carbenes; C-H activation; cobalt; cooperative catalysis; isoquinolinones; ONE-POT SYNTHESIS; SELECTIVE ALKENYLATION; OXIDATIVE ANNULATION; AROMATIC KETIMINES; ARYLZINC REAGENTS; ALKYNES; IMINES; ROUTE; DERIVATIVES; AMIDATION;
D O I：
10.1002/anie.201601003
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile route toward the synthesis of isoquinolin-3-ones through a cooperative B(C6F5)(3)- and Cp*Co-III-catalyzed C-H bond activation of imines with diazo compounds is presented. The inclusion of a catalytic amount of B(C6F5)(3) results in a highly efficient reaction, thus enabling unstable NH imines to serve as substrates.
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页码：5577 / 5581
页数：5
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