Time Course of Bone Loss in Patients with Anorexia Nervosa

被引：22

作者：

Olmos, Jose M. ^{[1
,2
]}

Valero, Carmen ^{[2
]}

del Barrio, Andres Gomez

Amado, Jose A. ^{[2
]}

Hernandez, Jose L. ^{[2
]}

Menendez-Arango, Jose

Gonzalez-Macias, Jesus ^{[2
]}

机构：

[1] Univ Cantabria, Hosp Univ Marques de Valdecilla, Div Psychiat, RETICEF,Dept Med Interna, Santander 39008, Spain

[2] Univ Cantabria, Hosp Univ Marques de Valdecilla, Dept Internal Med, RETICEF, Santander 39008, Spain

来源：

INTERNATIONAL JOURNAL OF EATING DISORDERS | 2010年 / 43卷 / 06期

关键词：

anorexia nervosa; bone mineral density; weight recovery; MINERAL DENSITY; EATING-DISORDERS; FEMALE ADOLESCENTS; WEIGHT-GAIN; YOUNG-WOMEN; FOLLOW-UP; OSTEOPOROSIS; OSTEOPENIA; RECOVERY; PREVALENCE;

D O I：

10.1002/eat.20731

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Objective: To evaluate the time course of bone mineral density (BMD) in women with anorexia nervosa (AN) during 2-year follow-up. Method: We prospectively studied 51 female with AN aged 18-38 years, and 40 age-matched healthy women (19-34 years). BMD was measured in lumbar spine (LS), femoral neck (FN), and total hip (TH) by DXA. Results: At baseline, weight, body mass index, and lumbar and hip BMD were significantly (p < .001) lower in AN patients than in controls. Patients who gain weight showed a significant increase in BMD at FN (+1.6%; p < .05), and TH(+4.4%; p < .05) and lower nonsignificant changes in LS (+1.3%). Weight at entry, and percent change of weight were significant determinants (p < .05) of the variability in percent change of BMD at FN and TH, whereas weight at entry was the main determinant of bone modifications at lumbar spine. Discussion: Our data emphasize the influence of weight gain in recovery of bone mass in AN patients, especially at the hip. (C) 2009 by Wiley Periodicals, Inc.

引用

页码：537 / 542

页数：6

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